Crystal structure resolution of two different chlorhexidine salts.
Crystal structure resolution of two different chlorhexidine salts.
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DOI：
10.1016/j.molstruc.2016.04.077
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发表时间：
2016-10-05
影响因子：
3.8
通讯作者：
Morris RE
中科院分区：
文献类型：
--
作者：
Cattaneo D;McCormick LJ;Cordes DB;Slawin AM;Morris RE
合成了氯己定双阳离子（H_2CH_x ~（2+））-（H_2CH_x）（SO_4）·3H_2O和（H_2CH_x）（CO_3）·4H_2O-的两种盐，并进行了晶体学表征。制备了两种氯己定二价盐的晶体。氯己定阳离子上的质子化位点在两种盐之间是不同的。两种盐的阳离子和阴离子堆积非常相似。不同的氢键相互作用发生在CO 32 −和SO 42 −盐之间。
Two salts of the chlorhexidine di-cation (H2CHx2+) – (H2CHx)(SO4)·3H2O and (H2CHx)(CO3)·4H2O – have been synthesised and characterised crystallographically. Crystals of two salts of the chlorhexidine dication have been prepared. The protonation sites on the chlorhexidine cation are different between the two salts. The cation and anion packing is very similar for both salts. Different hydrogen-bonding interactions occur between the CO32− and SO42− salts.