Detection of air trapping in chronic obstructive pulmonary disease by low frequency ultrasound
Detection of air trapping in chronic obstructive pulmonary disease by low frequency ultrasound
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DOI：
10.1186/1471-2466-12-8
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发表时间：
2012-03-16
影响因子：
3.1
通讯作者：
Hohlfeld, Jens M.
中科院分区：
文献类型：
--
作者：
Morenz, Katrin;Biller, Heike;Hohlfeld, Jens M.
背景：肺活量测定被认为是诊断慢性阻塞性肺疾病的金标准，但该疾病被普遍低估。因此，需要更多易于执行和解释的筛查方法。最近，我们证实了低频超声(LFU)可能有助于肺部疾病的监测。本研究的目的是评估LFU是否可以用来检测COPD患者的空气滞留。方法：对17例慢性阻塞性肺疾病患者和9例健康体检者进行了人体体积描记和LFU检查。在吸气和呼气期间，超声频率从1到40 kHz传输到胸骨，并在背部接收。吸气信号和呼气信号的高通频率及其差值称为Delta F，吸入沙丁胺醇后重复测量。结果：COPD患者与健康人的Delta F有显著差异。这些差异在GOLD阶段1已经显著，并随着COPD的严重程度而增加。对黄金分期1的敏感性为83%，对1级以下的敏感性为91%。结论：低频超声具有成本低、操作简便等优点，适用于空气滞留的检测。这对COPD的筛查可能是有用的。
Background: Spirometry is regarded as the gold standard for the diagnosis of COPD, yet the condition is widely underdiagnosed. Therefore, additional screening methods that are easy to perform and to interpret are needed. Recently, we demonstrated that low frequency ultrasound (LFU) may be helpful for monitoring lung diseases. The objective of this study was to evaluate whether LFU can be used to detect air trapping in COPD. In addition, we evaluated the ability of LFU to detect the effects of short-acting bronchodilator medication.Methods: Seventeen patients with COPD and 9 healthy subjects were examined by body plethysmography and LFU. Ultrasound frequencies ranging from 1 to 40 kHz were transmitted to the sternum and received at the back during inspiration and expiration. The high pass frequency was determined from the inspiratory and the expiratory signals and their difference termed Delta F. Measurements were repeated after inhalation of salbutamol.Results: We found significant differences in Delta F between COPD subjects and healthy subjects. These differences were already significant at GOLD stage 1 and increased with the severity of COPD. Sensitivity for detection of GOLD stage 1 was 83% and for GOLD stages worse than 1 it was 91%. Bronchodilator effects could not be detected reliably.Conclusions: We conclude that low frequency ultrasound is cost-effective, easy to perform and suitable for detecting air trapping. It might be useful in screening for COPD.