Zika Virus Disease in Children in Colombia, August 2015 to May 2016
Zika Virus Disease in Children in Colombia, August 2015 to May 2016
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DOI：
10.1111/ppe.12391
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发表时间：
2017-11-01
影响因子：
2.8
通讯作者：
Ospina Martinez, Martha L.
中科院分区：
文献类型：
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作者：
Tolosa, Natalia;Tinker, Sarah C.;Ospina Martinez, Martha L.
寨卡病毒感染的危害有哪些？然而，关于儿童寨卡病毒感染的数据很少。MethodsWe分析了2015-2016年寨卡病毒爆发期间哥伦比亚国家监测系统对1个月至18岁儿童中符合寨卡病毒病（ZVD）临床病例定义的患者的数据，以估计人口统计学特征的发病率并描述选定并发症的发生。2016年5月28日，在1个月至18岁的儿童中报告了18576例出生后ZVD病例。实验室检测优先用于高风险患者（婴儿、孕妇、65岁以上的成年人和有严重合并症的人）;在1655例实时逆转录聚合酶链反应检测中，1207例（72.9%）为阳性。报告的ZVD累积发生率为114.4/100000。发病率因性别而异，取决于年龄组;在15- 18奥尔兹中观察到最大的差异，女性的发病率高于男性（累积发病率比2.5，95%置信区间2.3，2.7）。在监测系统的报告时间，631例（3.4%）住院治疗，96（0.5%）有一个伴随的神经系统诊断，包括格林-巴利综合征40 patients.ConclusionsOnly一小部分的报告儿科ZVD病例在哥伦比亚住院或报告神经系统疾病ZVD后。然而，一些严重后果的可能性表明了预防儿童寨卡病毒感染的重要性。
BackgroundChildren are considered a potentially vulnerable population for Zika virus infection. However, data on paediatric Zika virus infection are sparse.MethodsWe analysed data from Colombia's national surveillance system during the 2015-2016 Zika virus outbreak on patients meeting the clinical case definition of Zika virus disease (ZVD) among children aged 1month to 18years to estimate incidence by demographic characteristics and characterize the occurrence of selected complications.ResultsBetween August 14, 2015, and May 28, 2016, there were 18576 reported cases of postnatal ZVD among children aged 1month to 18years. Laboratory testing was prioritized for high-risk patients (infants, pregnant women, adults aged 65years, and persons with serious co-morbidities); among 1655 that were tested by real-time reverse transcriptase polymerase chain reaction, 1207 (72.9%) were positive. The cumulative incidence of reported ZVD was 114.4 per 100000. The incidence differed by sex, depending on age group; the largest difference was observed for 15-18year olds, with females having a higher incidence than males (cumulative incidence ratio 2.5, 95% confidence interval 2.3, 2.7). At the time of report to the surveillance system, 631 patients (3.4%) were hospitalised and 96 (0.5%) had a report of an accompanying neurological diagnosis, including Guillain-Barre syndrome in 40 patients.ConclusionsOnly a small proportion of reported paediatric ZVD cases in Colombia were hospitalized or had reported neurological conditions following ZVD. However, the potential for some serious outcomes demonstrates the importance of preventing Zika virus infection in children.