Fetal hemoglobin reactivation in baboon and man: a short perspective.
Fetal hemoglobin reactivation in baboon and man: a short perspective.
复制标题
狒狒和人类胎儿血红蛋白再激活：短期视角。
DOI：
10.1002/ajh.2830420118
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发表时间：
1993
影响因子：
12.8
通讯作者：
Heller,P
中科院分区：
文献类型：
--
作者：
Lavelle,D;DeSimone,J;Heller,P
Present concepts of the mechanism of reactivation of synthesis of fetal hemoglobin (HbF) in the adult under conditions of erythropoietic stress are briefly reviewed. Since HbF can be considered an effective natural antisickling agent, the reactivation of its synthesis in patients with sickle cell anemia as a desirable therapeutic goal has been extensively explored since the discovery in 1982 that 5‐azacytidine increases HbF levels in the baboon. Hydroxyurea (HU) has become the most widely used agent, although its effectiveness in increasing HbF levels and the number of F cells is highly variable. Recent investigations are cited showing that other agents such as butyrate, and the addition of recombinant hemopoietic growth factors, such as erythropoietin and stem cell factor, especially in combination with HU, offer important therapeutic possibilities. Transacting nuclear proteins are briefly discussed as possibly having a future role in the efforts of stimulating γ‐chain synthesis. © 1993 Wiley‐Liss, Inc.
