The Effect of Fibroblast Growth Factor 9 on the Osteogenic Differentiation of Calvaria-Derived Mesenchymal Cells
The Effect of Fibroblast Growth Factor 9 on the Osteogenic Differentiation of Calvaria-Derived Mesenchymal Cells
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成纤维细胞生长因子9对颅盖间充质细胞成骨分化的影响
DOI：
10.1097/scs.0000000000001053
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发表时间：
2014-09-01
影响因子：
0.9
通讯作者：
Shen, Guofang
中科院分区：
文献类型：
--
作者：
Lu, Jingting;Dai, Jiewen;Shen, Guofang
成纤维细胞生长因子9（FGF9）在骨形成中发挥着复杂而关键的作用，FGF9的生物学效应可能取决于基因剂量、发育阶段、细胞类型或与其他细胞因子的相互作用。在这项研究中，我们证明 FGF9 增强了颅盖源性间充质细胞中细胞外调节蛋白激酶 1/2 的磷酸化。然而，FGF9对颅盖间充质细胞成骨分化的抑制作用并不依赖于细胞外调节蛋白激酶1/2的磷酸化。结合前期FGF9在体外促进牙髓干细胞软骨形成的研究结果，我们认为FGF9可能应用于体外促进间充质干细胞软骨形成并抑制成骨。
Fibroblast growth factor 9 (FGF9) plays complicated and crucial roles in bone formation, and the biologic effect of FGF9 may depend on the gene dosage, developmental stage, cell type, or interactions with other cytokines. In this study, we demonstrated that FGF9 enhanced the phosphorylation of extracellular regulated protein kinases 1/2 in calvaria-derived mesenchymal cells. However, the inhibitory effect of FGF9 on the osteogenic differentiation of calvaria-derived mesenchymal cells did not depend on the phosphorylation of extracellular regulated protein kinases 1/2. Combined with the previous findings that FGF9 promotes dental pulp stem cells chondrogenesis in vitro, we suggest that FGF9 may be applied to promote chondrogenesis and inhibit osteogenesis in mesenchymal stem cells in vitro.