BONE-MARROW ANGIOGENESIS AND PROGRESSION IN MULTIPLE-MYELOMA
BONE-MARROW ANGIOGENESIS AND PROGRESSION IN MULTIPLE-MYELOMA
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DOI：
10.1111/j.1365-2141.1994.tb08304.x
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发表时间：
1994-07-01
影响因子：
6.5
通讯作者：
DAMMACCO, F
中科院分区：
文献类型：
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作者：
VACCA, A;RIBATTI, D;DAMMACCO, F
肿瘤生长依赖于血管生成。我们发现，在多发性骨髓瘤（MM）患者和单克隆伽玛病（MGUS）患者中，骨髓血管生成的程度（以微血管面积评估）与骨髓浆细胞的增殖（s期）分数（以标记指数（LI）评估）之间存在高度相关性。血管生成本身与活动性MM和MGUS显著相关，而非活动性MM和MGUS。微血管面积最大，伴急性进行性MM， LI最高。当使用微血管面积的2%或更大的临界值时，大多数活动性MM患者被正确分类。MM患者活动性疾病的风险随着微血管面积的增加而增加。浆细胞的生长、活动阶段与骨髓血管生成之间存在因果关系。由于血管生成与浆细胞肿瘤的扩大和MM的活动期同步进行，因此其测量可能是浆细胞增生性疾病患者的有用预后标志物。
Tumour growth is angiogenesis-dependent. We found a high correlation between the extent of bone marrow angiogenesis, evaluated as microvessel area, and the proliferating (S-phase) fraction of marrow plasma cells, evaluated as labelling index (LI), in patients with multiple myeloma (MM) and in those with monoclonal gammopathies of undetermined significance (MGUS). Angiogenesis itself was significantly associated with active as opposed to non-active MM and MGUS. The highest microvessel area accompanied rapidly progressive MM with the highest LI. When a cut-off value of 2% or greater of the microvessel area was used, most patients with active MM were classified correctly. The risk of active disease in patients with MM increased in parallel with the microvessel area. A causal relationship between plasma cell growth, activity phase in MM and marrow angiogenesis is suggested. Since angiogenesis proceeds in step with the enlargement of plasma cell tumours and the activity phase in MM, its measurement could be a useful prognostic marker in patients with plasma cell proliferative disorders,