High Expression of Macrophage Colony-Stimulating Factor-1 Receptor in Peritumoral Liver Tissue Is Associated with Poor Outcome in Hepatocellular Carcinoma After Curative Resection
High Expression of Macrophage Colony-Stimulating Factor-1 Receptor in Peritumoral Liver Tissue Is Associated with Poor Outcome in Hepatocellular Carcinoma After Curative Resection
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瘤周肝组织中巨噬细胞集落刺激因子1受体的高表达与肝细胞癌根治性切除后的不良预后相关
DOI：
10.1634/theoncologist.2009-0170
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发表时间：
2010-07-01
期刊：
影响因子：
5.8
通讯作者：
Tang, Zhao-You
中科院分区：
文献类型：
--
作者：
Jia, Jin-Bin;Wang, Wen-Quan;Tang, Zhao-You
背景。巨噬细胞集落刺激因子 1 受体 (CSF-1R) 在肝细胞癌 (HCC) 中的表达及其预后价值尚不清楚。本研究评估了根治性切除后HCC患者瘤内和瘤周表达的CSF-1R的预后价值。方法。构建了包含来自队列 1（105 名患者）和队列 2（32 名患者）材料的组织微阵列。进行免疫组织化学分析并评估这些数据和其他临床病理学数据的预后价值。通过实时定量聚合酶链反应评估第 3 组（52 名患者）中的 CSF-1R mRNA 水平。结果。瘤周肝组织中CSF-1R密度及其mRNA水平均显着高于相应肿瘤组织。 CSF-1R在长距离瘤周组织芯片中呈梯度分布，其密度随着距肿瘤边缘距离的增加而降低。高瘤周 CSF-1R 与更多的肝内转移和较差的生存率显着相关。瘤周CSF-1R是总生存率和复发时间的独立预后因素，并影响早期复发的发生率。然而，瘤内 CSF-1R 与任何临床病理特征均不相关。瘤周 CSF-1R 还与小 HCC 亚组的总生存率和复发时间相关。
Background. Macrophage colony-stimulating factor 1 receptor (CSF-1R) expression in hepatocellular carcinoma (HCC) and its prognostic values are unclear. This study evaluated the prognostic values of the intratumoral and peritumoral expression of CSF-1R in HCC patients after curative resection.Methods. Tissue microarrays containing material from cohort 1 (105 patients) and cohort 2 (32 patients) were constructed. Immunohistochemistry was performed and prognostic values of these and other clinicopathological data were evaluated. The CSF-1R mRNA level was assessed by quantitative real-time polymerase chain reaction in cohort 3 (52 patients).Results. Both the CSF-1R density and its mRNA level were significantly higher in peritumoral liver tissue than in the corresponding tumor tissue. CSF-1R was distributed in a gradient in the long-distance peritumoral tissue microarray, with its density decreasing as the distance from the tumor margin increased. High peritumoral CSF-1R was significantly associated with more intrahepatic metastases and poorer survival. Peritumoral CSF-1R was an independent prognostic factor for both overall survival and time to recurrence and affected the incidence of early recurrence. However, intratumoral CSF-1R did not correlate with any clinicopathological feature. Peritumoral CSF-1R was also associated with both overall survival and time to recurrence in a subgroup with small HCCs (