Analysis of Japanese encephalitis epidemic in western Nepal in 1997
Analysis of Japanese encephalitis epidemic in western Nepal in 1997
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DOI：
10.1017/s0950268801004769
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发表时间：
2001-02-01
影响因子：
4.2
通讯作者：
Umenai, T
中科院分区：
文献类型：
--
作者：
Akiba, T;Osaka, K;Umenai, T
我们对1997年尼泊尔西南部爆发的日本脑炎（JE）进行了流行病学研究，发现研究地区JE感染密度很高，估计研究地区总人口的27.9%感染了JE病毒。病死率为13.2%，5岁以上男女病死率无差异。然而，在5岁以下儿童中，女性的病死率是男性的2.1倍（14.6%对6.9%）。1998年流行期间，从疑似乙脑病例中采集了53份血液样本。乙脑特异性IgM的结果显示，在三家合作医院中，平均78%（70- 93%）的患者的乙脑临床诊断得到血清学证实。这些研究表明，乙脑在该地区的流行率很高，临床诊断是可靠的。对于这种疫苗可预防的疾病，应采取有效的预防措施。
We conducted an epidemiological study of a Japanese encephalitis (JE) outbreak in the southwestern part of Nepal in 1997, A high density of JE infections was found and it was estimated that 27.9 % the total population were infected with JE virus in the study area. The fatality rate was 13.2 % and there was no difference in the fatality rate between males and females over 5 years old. However, the case fatality rate was 2.1 times higher in females than in males (14.6 % vs. 6.9 %) among children under 5 years of age. Fifty-three blood samples were collected from suspected JE cases during the epidemic period in 1998. Findings for JE specific IgM revealed that clinical diagnoses of JE were serologically confirmed in an average 78 % (70-93 %) of patients in three collaborating hospitals. These studies demonstrated that JE was highly prevalent in the area and clinical diagnoses were reliable. Effective preventive measures should be taken against this vaccine-preventable disease.