Effects of continuous exposure to light on behavioral dopaminergic supersensitivity
Effects of continuous exposure to light on behavioral dopaminergic supersensitivity
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DOI：
10.1016/s0006-3223(98)00305-9
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发表时间：
1999-06-15
影响因子：
10.6
通讯作者：
Frussa, R
中科院分区：
文献类型：
--
作者：
Abílio, VC;Freitas, FM;Frussa, R
背景：本研究探讨了长期持续光照对氟哌啶醇忏悔处理所致大鼠多巴胺能超敏反应的影响。方法：以大鼠旷场自发一般活动(SGA)和阿朴吗啡或苯丙胺(SB-AMP)刻板行为(SB-AMP)为实验参数。每组动物随机分为4组：生理盐水组处于12h光暗周期(LD)或24h光/光周期(LL)下，氟哌啶醇组动物处于上述周期下。用放射免疫法测定LD和LL周期下生理盐水处理的MTS大鼠血浆皮质酮浓度。结果：所有行为学参数均显示两种周期下大鼠的中枢性多巴胺能超敏反应。持续光照可增加生理盐水和氟哌啶醇处理的MTS的SGA和SB-AMP，但不改变SB-APO。处于长周期的动物血浆皮质酮浓度升高。结论：我们的结果表明，持续暴露在光照下会导致正常和超敏感大鼠的多巴胺能功能增加。这一效应似乎是由突触前机制介导的，可能涉及皮质酮的作用。(C)1999年生物精神病学学会。
Background: This study examines the effects of long-term continuous exposure to light on dopaminergic supersensitivity induced by repented treatment with haloperidol in rats,Methods: Spontaneous general activity in an open-field (SGA) and stereotyped behavior induced by apomorphine (SB-APO) or amphetamine (SB-AMP) were used as experimental parameters. Rats were allocated to four groups in each experiment: saline-treated animals kept under a 12-hour light/dark cycle (LD) or 24-hour light/light cycle (LL), and 2 mg/kg haloperidol-treated animals kept under the above cycles. Plasma corticosterone concentration was also measured by radioimunoassay in saline-treated mts kept under a LD or LL cycle.Results: All the behavioral parameters used showed the development of central dopaminergic supersensitivity in rats kept under both cycles. Continuous exposure to light enhanced SGA and SB-AMP in both saline- and haloperidol-treated mts, but did not modify SB-APO. Animals kept under the LL cycle presented an increased plasma corticosterone concentration.Conclusions: Our results suggest that continuous exposure to light leads to an increase in dopaminergic function in both normal and "supersensitive" rats. This effect seems to be mediated by a presynaptic mechanism possibly involving corticosterone actions. (C) 1999 Society of Biological Psychiatry.