Photodynamic therapy as an adjunct to non-surgical periodontal treatment:: A randomized, controlled clinical trial
Photodynamic therapy as an adjunct to non-surgical periodontal treatment:: A randomized, controlled clinical trial
复制标题
DOI：
10.1902/jop.2008.070652
复制
发表时间：
2008-09-01
影响因子：
4.3
通讯作者：
Sculean, Anton
中科院分区：
文献类型：
--
作者：
Christodoulides, Nicos;Nikolidakis, Dimitris;Sculean, Anton
背景：最近的临床前和临床数据表明光动力疗法（PDT）在牙周炎治疗中具有潜在的益处。然而，有非常有限的数据，从对照临床试验评价PDT治疗牙周炎的效果。本研究的目的是评估的临床和微生物学的影响，连续使用PDT的非手术牙周treatment.Methods：24例慢性牙周炎随机治疗与缩放和根面平整，其次是一个单一的情节PDT（测试）或缩放和根面平整单独（对照）。在基线和治疗后3个月和6个月测量全口菌斑评分（FMPS）、全口出血评分（FMBS）、探诊深度（PD）、牙龈退缩和临床附着水平（CAL）。主要结果变量是PD和CAL的变化。对伴放线聚集杆菌（以前为伴放线放线杆菌）、牙龈卟啉单胞菌、中间普雷沃菌、嗜酸坦纳菌（以前为嗜酸坦纳菌）的微生物学评价。Eikenella corrodens）和二氧化碳噬纤维菌属（Capnocytophaga spp.）在基线和3个月和6个月后，通过使用市售的聚合酶链反应test.Results：在治疗后3个月和6个月，有没有统计学上的显着差异，两组之间的CAL，PD，FMPS，或微生物的变化。在3个月和6个月，一个统计学上显着更大的改善FMBS被发现在test group.Conclusion：额外的应用程序的一个单一的情节PDT缩放和根面平整未能导致额外的改善方面的PD减少和CAL增益，但它导致了一个显着更高的减少出血分数相比，缩放和根面平整。
Background: Recent preclinical and clinical data have suggested a potential benefit of photodynamic therapy (PDT) in the treatment of periodontitis. However, there are very limited data from controlled clinical trials evaluating the effect of PDT in the treatment of periodontitis. The aim of this study was to evaluate the clinical and microbiologic effects of the adjunctive use of PDT to non-surgical periodontal treatment.Methods: Twenty-four subjects with chronic periodontitis were randomly treated with scaling and root planing followed by a single episode of PDT (test) or scaling and root planing alone (control). Full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing depth (PD), gingival recession, and clinical attachment level (CAL) were measured at baseline and 3 and 6 months after therapy. Primary outcome variables were changes in PD and CAL. Microbiologic evaluation of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia (previously T. forsythensis), Treponema denticola, Parvimonas micra (previously Peptostreptococcus micros or Micromonas micros), Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, and Capnocytophaga spp. was performed at baseline and 3 and 6 months following therapy by using a commercially available polymerase chain reaction test.Results: At 3 and 6 months after treatment, there were no statistically significant differences between the groups with regard to CAL, PD, FMPS, or microbiologic changes. At 3 and 6 months, a statistically significantly greater improvement in FMBS was found in the test group.Conclusion: The additional application of a single episode of PDT to scaling and root planing failed to result in an additional improvement in terms of PD reduction and CAL gain, but it resulted in a significantly higher reduction in bleeding scores compared to scaling and root planing alone.