Clinical evaluation of dynamic arc conformal radiotherapy for paraaortic lymph node metastasis
Clinical evaluation of dynamic arc conformal radiotherapy for paraaortic lymph node metastasis
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DOI：
10.1016/s0167-8140(02)00388-2
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发表时间：
2003-04-01
影响因子：
5.7
通讯作者：
Hiraoka, M
中科院分区：
文献类型：
--
作者：
Aoki, T;Nagata, Y;Hiraoka, M
目的：本研究旨在评价动态弧形适形放射治疗（一种简单的调强放射治疗（IMRT））治疗主动脉旁淋巴结转移瘤的有效性和安全性。计划总剂量为55-60戈伊。结果：全组放射剂量50 ~ 63.4戈伊，中位剂量60戈伊。29例中16例CT显示肿瘤局部缩小，2年无复发生存率为58%。急性1级和2级胃肠道疾病的发生率分别为31%和17%，急性2级肝功能障碍的发生率为7%。作为晚期并发症，分别有6例患者（21%）和5例患者（17%）发生I级和2级肝功能障碍。结论：动态弧形适形放疗是一种简单的调强放疗方法，是治疗腹主动脉旁淋巴结转移瘤安全、有效的方法。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Purpose: This study was performed to evaluate the efficacy and safety of dynamic arc conformal radiotherapy, a simple intensity modulated radiation therapy (IMRT), for the treatment of paraaortic lymph node metastases.Materials and methods: Twenty-nine patients with paraaortic lymph node metastases were enrolled in this study. The total planned dose was 55-60 Gy. A computed tomography (CT) simulator was used in the treatment planning.Results: The total radiation dose delivered was 50-63.4 Gy (median 60 Gy). Sixteen of 29 patients showed local tumor shrinkage on CT, and the 2 year in-field recurrence free survival rate was 58%. Acute Grade 1 and Grade 2 gastrointestinal disorders occurred in 31% and 17%, respectively, and acute Grade 2 liver dysfunction occurred in 7%. As a late complication, Grade I and Grade 2 liver dysfunction occurred in six patients (21%) and five patients (17%), respectively. There was no renal dysfunction or myelopathy detected.Conclusion: Dynamic arc conformal radiotherapy, a simple IMRT, is a safe and effective treatment method for paraaortic lymph node metastasis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.