Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort
Prenatal ambient air pollution exposure, infant growth and placental mitochondrial DNA content in the INMA birth cohort
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DOI：
10.1016/j.envres.2017.05.018
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发表时间：
2017-08-01
影响因子：
8.3
通讯作者：
Vrijheid, Martine
中科院分区：
文献类型：
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作者：
Clemente, Diana B. P.;Casas, Maribel;Vrijheid, Martine
背景：产前空气污染暴露与产后生长之间的关系几乎没有被探讨。线粒体DNA（mtDNA），作为氧化应激的标志物，和生长在出生时可以发挥中间作用，在此association.Objective：在西班牙出生队列INMA的一个子集，我们首先评估是否产前二氧化氮（NO2）暴露与婴儿的生长。其次，我们评估了出生时的生长（身高和体重）是否可以在这种关联中发挥中介作用。方法：对336例INMA患儿进行胎盘线粒体DNA相对含量测定。土地利用回归模型被用来估计产前NO2暴露。婴儿生长（身高和体重）在出生时，在6个月的年龄，并在1岁的年龄进行了评估。我们使用了多元线性回归模型，并进行了中介分析。中介的比例计算为间接影响的总effects.Results的比例：产前NO2暴露与所有婴儿的生长参数呈负相关。在妊娠第一个三个月期间，产前NO2暴露量增加10 μ g/m3与6个月时的身高（-6.6%; 95%CI：-11.4，-1.9）和1岁时的体重（-4.2%; 95%CI：-8.3，-0.1）呈显著负相关。这些关联分别由出生身长（31.7%; 95%CI：34.5，14.3）和体重（53.7%; 95%CI：65.3，-0.3）介导。此外，5.5%（95%CI：10.0，-0.2）之间的关联第1孕期NO2暴露和长度在6个月龄可以介导的胎盘mtDNA contents.Conclusions：我们的研究结果表明，胎儿生长受损产前空气污染暴露造成的可能会导致婴儿生长受损在生命的第一年。此外，胎盘mtDNA的分子适应与空气污染引起的生长变化的出生后后果有关。
Background: The association between prenatal air pollution exposure and postnatal growth has hardly been explored. Mitochondrial DNA (mtDNA), as a marker of oxidative stress, and growth at birth can play an intermediate role in this association.Objective: In a subset of the Spanish birth cohort INMA we assessed first whether prenatal nitrogen dioxide (NO2) exposure is associated with infant growth. Secondly, we evaluated whether growth at birth (length and weight) could play a mediating role in this association. Finally, the mediation role of placental mitochondrial DNA content in this association was assessed.Methods: In 336 INMA children, relative placental mtDNA content was measured. Land-use regression models were used to estimate prenatal NO2 exposure. Infant growth (height and weight) was assessed at birth, at 6 months of age, and at 1 year of age. We used multiple linear regression models and performed mediation analyses. The proportion of mediation was calculated as the ratio of indirect effect to total effect.Results: Prenatal NO2 exposure was inversely associated with all infant growth parameters. A 10 mu g/m(3) increment in prenatal NO2 exposure during trimester 1 of pregnancy was significantly inversely associated with height at 6 months of age (-6.6%; 95%CI: -11.4, -1.9) and weight at 1 year of age (-4.2%; 95%CI: -8.3, -0.1). These associations were mediated by birth length (31.7%; 95%CI: 34.5, 14.3) and weight (53.7%; 95%CI: 65.3, -0.3), respectively. Furthermore, 5.5% (95%CI: 10.0, -0.2) of the association between trimester 1 NO2 exposure and length at 6 months of age could be mediated by placental mtDNA content.Conclusions: Our results suggest that impaired fetal growth caused by prenatal air pollution exposure can lead to impaired infant growth during the first year of life. Furthermore, molecular adaptations in placental mtDNA are associated with postnatal consequences of air pollution induced alterations in growth.