Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris
Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris
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DOI：
10.1016/s0190-9622(99)70076-9
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发表时间：
1999-06-01
影响因子：
13.8
通讯作者：
Krueger, JG
中科院分区：
文献类型：
--
作者：
Walters, IB;Burack, LH;Krueger, JG
背景：窄谱 UVB (NB-UVB) 是牛皮癣的一种新的光疗选择。先前使用不同 UVB 波长进行的作用光谱研究表明，亚红斑剂量的 NB-UVR 对于治疗寻常型银屑病可能非常有效。即便如此，之前还没有进行过亚红斑剂量的 NE 与传统 UVB 的比较研究。 目的：我们的目的是比较传统宽带 UVB (BB-UVB) 与亚红斑剂量的 NB-UVB 治疗寻常型银屑病的效果。 方法：11 名患者采用分体法治疗，每周 3 次，为期 6 周。通过银屑病严重程度指数评分和定量组织学测量来评估结果。结果：我们能够在 NB-UVB 后 81.8% 的患者中诱导临床清除，但在 BB-UVB 后只有 9.1% 的患者出现临床清除（P
Background: Narrow-band UVB (NB-UVB) is a new phototherapy option for psoriasis. Action spectrum studies previously done with different UVB wavelengths suggest that suberythemogenic doses of NB-UVR could be highly effective in treating psoriasis vulgaris. Even so, no comparative studies with suberythemogenic doses of NE versus conventional UVB have been performed previously.Objective: Our purpose was to compare conventional broad-band UVB (BB-UVB) with NB-UVB at suberythemogenic doses for the treatment of psoriasis vulgaris.Methods: Eleven patients were treated using a split-body approach for 6 weeks on a three-times-a-week basis. Outcomes were evaluated by means of Psoriasis Severity Index scores and quantitative histologic measures.Results: We were able to induce clinical clearing in 81.8% of patients after NB-UVB, but in only 9.1% of patients after BB-UVB (P