A free-running DNA motor powered by a nicking enzyme
A free-running DNA motor powered by a nicking enzyme
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DOI：
10.1002/anie.200501262
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发表时间：
2005-01-01
影响因子：
16.6
通讯作者：
Turberfield, AJ
中科院分区：
文献类型：
--
作者：
Bath, J;Green, SJ;Turberfield, AJ
（图）DNA烧毁了它的桥：一个单向的分子马达，使寡核苷酸货物沿着自组装的轨道移动，是由磷酸二酯骨架的限制性内切酶水解提供动力的（见示意图）。限制酶对轨道造成的损坏阻止货物向后移动，因此施加方向性。© 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
(Figure Presented) DNA burns its bridges: A unidirectional molecular motor that moves an oligonucleotide cargo along a self-assembled track is powered by restriction endonuclease hydrolysis of the phosphodiester backbone (see scheme). Damage caused to the track by the restriction enzyme prevents the cargo from stepping backwards and therefore imposes directionality. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.