The environment and childhood asthma (ECA) study in Oslo: ECA-1 and ECA-2
The environment and childhood asthma (ECA) study in Oslo: ECA-1 and ECA-2
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DOI：
10.1034/j.1399-3038.13.s.15.2.x
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发表时间：
2002-01-01
影响因子：
4.4
通讯作者：
Carlsen, KCL
中科院分区：
文献类型：
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作者：
Carlsen, KCL
在20世纪80年代，奥斯陆观察到的哮喘入院率增加促使一项前瞻性出生队列研究提出以下问题：（广义上）空气污染（室外和室内）与幼儿哮喘的发生有关吗？从1992年1月1日起的12个月内，奥斯陆的3，754名儿童（出生体重大于或等于2000 g）在出生时就参加了环境和儿童哮喘（ECA）研究，并随访至2岁（ECA-第I部分）。在出生时收集脐带血、母亲填写的详细问卷（家族和妊娠疾病史、环境暴露、社会经济状况）和肺功能测量结果（n = 803）。每6个月完成一次详细的问卷调查，持续2年，包括儿童的疾病史、喂养习惯和环境暴露。一项巢式病例对照研究包括306名确诊至少两次支气管阻塞（rBO）的儿童和306名对照（无下呼吸道疾病），进行了临床研究（包括潮气呼吸肺功能、β-2反应性和过敏评估）和环境暴露评估（室内和室外）。家庭潮湿和低通风，以及母亲在怀孕期间吸烟，而不是室外空气污染增加了rBO的风险。母亲在怀孕期间吸烟的新生儿出生时肺功能下降。为了更好地了解哮喘和过敏发展的早期风险因素，对所有病例和对照组以及出生时测量肺功能的患者（共邀请1，230人）（9-10岁）进行了随访研究（2001年; ECA-第II部分）。这涉及临床调查、过敏评估、肺功能、气道高反应性测量、呼出的一氧化氮和免疫学以及过敏原暴露调查。
An observed increase in asthma admissions in Oslo during the 1980s prompted a prospective birth cohort study to ask the following question: was air pollution (outdoor and indoor) (in a broad sense) associated with asthma development in young children? During 12 months from 1 January 1992, 3,754 children (birth weight greater than or equal to2000 g) in Oslo were enrolled at birth into the Environment and Childhood Asthma (ECA) study and followed to 2 years of age (ECA-part I). Cord blood, a detailed questionnaire (family and pregnancy history of disease, environmental exposures, socio-economic status) completed by the mother and lung function measurements (n = 803) were collated at birth. Detailed questionnaires completed every 6 months for 2 years included the child's disease history, feeding habits and environmental exposures. A nested case-control study comprised 306 children with confirmed minimum two episodes of bronchial obstruction (rBO) and 306 controls (without lower respiratory tract disease) with clinical investigations (including tidal breathing lung function, beta-2 responsiveness and allergy assessment) and environmental exposure assessments (indoor and outdoor). Home dampness and low ventilation, as well as maternal smoking in pregnancy, but not outdoor air pollution increased the risk of rBO. Lung function at birth was decreased among newborns whose mother smoked during pregnancy. To understand better the early risk factors for asthma and allergy development, a follow-up study started (in 2001; ECA-part II) of all cases and controls, and those with lung function measured at birth (total 1,230 invited) (9-10 years of age). This involved clinical investigation, allergy assessments, lung function, airway hyper responsiveness measures, exhaled nitric oxide and immunological as well as allergen exposure investigations.