T-CELL RECEPTOR GENE REARRANGEMENT IN B-CELL NON-HODGKINS LYMPHOMA - CORRELATION WITH METHYLATION AND EXPRESSION
T-CELL RECEPTOR GENE REARRANGEMENT IN B-CELL NON-HODGKINS LYMPHOMA - CORRELATION WITH METHYLATION AND EXPRESSION
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DOI：
10.1016/0145-2126(89)90169-0
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发表时间：
1989-01-01
影响因子：
2.7
通讯作者：
NORTON, JD
中科院分区：
文献类型：
--
作者：
LEBER, BF;AMLOT, P;NORTON, JD
Two of 19 B-cell non-Hodgkin''s lymphoma (NHL) were found to have clonally rearranged T-cell receptor (TCR) beta chain genes with a germline TCR-gamma gene configuration. The inappropriate rearrangements had a similar structure to the TCR-beta rearrangements described in B-cell chronic lymphocytic leukemia. All cases analysed displayed a consistent germline transcription of TCR-beta and alpha chain genes which was independent of rearrangement. Consistent with this, all cases showed some degree of hypomethylation of the TCR-beta chain locus similar though distinguishable from the pattern seen in mature T cells, but quite different from that seen in normal mature B cells. Taken together, these data suggest that most NHL''s arise from an immature B-lymphocyte precursor at a stage of differentiation where lineage commitment is incomplete.
