Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer.
Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer.
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DOI：
10.1186/1471-2407-9-155
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发表时间：
2009-05-20
期刊：
影响因子：
3.8
通讯作者：
Kim HJ
中科院分区：
文献类型：
--
作者：
Kim DK;Oh SY;Kwon HC;Lee S;Kwon KA;Kim BG;Kim SG;Kim SH;Jang JS;Kim MC;Kim KH;Han JY;Kim HJ
白细胞介素-6（IL-6）通路是将炎症和血管生成与恶性肿瘤联系起来的机制之一。由于C-反应蛋白（CRP）是炎症的代表性标志物，CRP最近与许多癌症类型的疾病进展有关。本研究的主要目的是检测胃癌患者术前血清IL-6和CRP水平，并探讨其与胃癌病情及预后的关系。共115例接受胃切除术的患者入组本研究。采用酶联免疫吸附试验（ELISA）检测血清IL-6水平，采用免疫比浊法检测CRP水平。组织学结果包括肿瘤大小、肿瘤浸润深度、淋巴结（LN）转移和TNM分期（第6 AJCC分期分组：分期系统;原发肿瘤、区域LN、转移）。癌症侵袭和分期的增加通常与术前血清IL-6水平的增加相关。IL-6和CRP水平与浸润深度（P < 0.001，P = 0.001）、淋巴结转移（P < 0.001，P = 0.024）和TNM分期（P < 0.001，P < 0.001）相关。腹膜种植转移的存在与IL-6水平相关（P = 0.012）。当我们通过ROC曲线确定IL-6水平的临界值（6.77 pg/dL）时，我们注意到进展时间（TTP; P < 0.001）和总生存期（OS; P = 0.010）的显著差异。然而，CRP与患者的TTP和OS水平无显著性差异。血清IL-6水平与CRP水平呈正相关（r2 = 0.049，P = 0.018）。术前血清IL-6和CRP水平可作为判断肿瘤浸润、淋巴结转移和TNM分期的指标。术前高IL-6水平被认为是胃癌患者疾病复发和总生存的不良预后因素。
The interleukin-6 (IL-6) pathway is one of the mechanisms that link inflammation and angiogenesis to malignancy. Because the C-reactive protein (CRP) is a representative marker for inflammation, CRP has recently been associated with the progression of disease in many cancer types. The principal objective of this study was to determine the preoperative serum levels of IL-6 and CRP in gastric carcinoma, and to correlate them with disease status and prognosis. A total of 115 patients who underwent gastrectomy were enrolled in this study. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumor size, depth of tumor invasion, lymph node (LN) metastasis, and TNM stage (6th AJCC Stage Groupings: The staging systems; Primary tumor, regional LN, metastasis). Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels were correlated with invasion depth (P < 0.001, P = 0.001), LN metastasis (P < 0.001, P = 0.024) and TNM stage (P < 0.001, P < 0.001). The presence of peritoneal seeding metastasis is associated with IL-6 levels (P = 0.012). When we established the cutoff value for IL-6 level (6.77 pg/dL) by ROC curve, we noted significant differences in time to progression (TTP; P < 0.001) and overall survival (OS; P = 0.010). However, CRP evidenced no significance with regard to patients' TTP and OS levels. Serum IL-6 levels were correlated positively with CRP levels (r2 = 0.049, P = 0.018). Preoperative serum IL-6 and CRP levels might be markers of tumor invasion, LN metastasis, and TNM stage. Preoperative high IL-6 levels were proposed as a poor prognostic factor for disease recurrence and overall survival in patients with gastric cancers.
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影响因子：
11.5
作者：
Liao, Wei-Chih;Lin, Jaw-Town;Wu, Ming-Shiang
通讯作者：
Wu, Ming-Shiang
影响因子：
4.2
作者：
Watanabe, S;Mu, W;Johnson, RJ
通讯作者：
Johnson, RJ
影响因子：
9.6
作者：
Deans, D. A. C.;Wigmore, S. J.;Fearon, K. C. H.
通讯作者：
Fearon, K. C. H.
DOI：
10.1007/s10120-005-0315-x
发表时间：
2005-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Ashizawa, Tatsuto;Okada, Ryosuke;Aoki, Tatsuya
通讯作者：
Aoki, Tatsuya
影响因子：
4
作者：
Rawlings, JS;Rosler, KM;Harrison, DA
通讯作者：
Harrison, DA