BROAD SPECTRUM OF LEUKODERMA ACQUISITUM CENTRIFUGUM
BROAD SPECTRUM OF LEUKODERMA ACQUISITUM CENTRIFUGUM
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DOI：
10.1001/archderm.92.1.14
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发表时间：
1965-01-01
影响因子：
--
通讯作者：
SILBERBERG, I
中科院分区：
文献类型：
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作者：
KOPF, AW;MORRILL, SD;SILBERBERG, I
一系列不同的神经外胚层衍生的肿瘤与白癜风的晕提出。临床上，这些病变通常位于中心位置，通常是色素沉着的肿瘤，周围是低色素沉着区。组织学表现包括表皮黑色素减少或缺失，但白皮晕中无色素黑素细胞持续存在；各种肿瘤，包括痣细胞痣、神经样痣、蓝色痣、神经纤维瘤和恶性黑色素瘤；数量不定的“小暗细胞”，性质不明，可能部分代表小痣细胞，部分代表淋巴样细胞；对一些肿瘤细胞造成损伤这可能是导致肿瘤细胞死亡的原因。此外，还介绍了酪氨酸酶活性的组织化学证明和肿瘤中存在γ -球蛋白的免疫组织化学研究。使用荧光抗体技术不可能显示患者血清中针对肿瘤的γ -球蛋白。讨论了皮肤神经外胚层源性肿瘤自发消退与色素减退的关系。
A series of diverse neuroectodermally derived tumors associated with halos of leukoderma is presented. Clinically these lesions have in common a centrally placed, usually pigmented tumor encircled by a zone of hypopigmentation. The histological findings include reduction or absence of epidermal melanin, but persistence of amelanotic melanocytes in the leukodermic halo; a variety of tumors including nevus-cell nevus, neuroid nevus, blue nevus, neurofibroma, and malignant melanoma; variable numbers of "small dark cells" whose nature is unclear, and which probably represent in part small nevus cells and in part lymphoid cells; and damage to some tumor cells which presumably could be the cause of their destruction. Also presented are histochemical demonstrations of tyrosinase activity and immunohisto-chemical studies for presence of gamma-globulin in the tumors. Using the fluorescent antibody technique it was not possible to show gamma-globulins in patients'' sera directed against their tumors. The relationship of developing hypopigmentation to the spontaneous regression of cutaneous neuroectodermally derived tumors is discussed.