A potentially oncogenic human papillomavirus (HPV-5) found in two renal allograft recipients.
A potentially oncogenic human papillomavirus (HPV-5) found in two renal allograft recipients.
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在两名同种异体肾移植受者中发现了一种潜在致癌性人乳头瘤病毒 (HPV-5)。
DOI：
10.1111/1523-1747.ep12531131
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
G. Orth
中科院分区：
文献类型：
--
作者：
M. Lutzner;O. Croissant;M. Ducasse;H. Kreis;J. Crosnier;G. Orth
我们观察了2例免疫抑制的同种异体肾移植受者，他们的皮肤由人乳头瘤病毒5型(HPV-5)引起。1名受者在手臂和躯干上有多处花斑疹样(PV样)皮损，以及多处Bowen样原位皮肤癌。另一个在她的指背上有两个疣状病变。用免疫荧光法在两例良性病变中检测到人乳头瘤病毒5型结构抗原。在这两个患者的皮损中观察到的组织学和超微结构特征与以前在罕见疾病疣状表皮发育不良(EV)患者中HPV-5诱导的皮损中看到的相似。严重形式的EV的特点是HPV-5诱导的PV样病变，多发性皮肤癌，通常是细胞免疫功能低下。在我们的一位肾移植受者身上看到的照片让人想起了这种严重的EV。到目前为止，HPV-5只在EV患者中发现。这种潜在的致癌病毒在皮肤癌中的作用必须确定，皮肤癌已知在免疫抑制的肾移植受者中发生的频率增加。
We have observed 2 immunosuppressed renal allograft recipients with skin lesions induced by human papillomavirus type 5 (HPV-5). One recipient had multiple pityriasis versicolor-like (PV-like) skin lesions on his arms and trunk, and multiple Bowenoid in-situ skin cancers. The other had 2 warty lesions on the back of her fingers. Structural antigens of human papillomavirus type 5 (HPV-5) were identified in benign lesions from both patients by immunofluorescence. The histologic and ultrastructural features observed in lesions from both patients were similar to those previously seen in HPV-5-induced lesions occurring in patients with the rare disease epidermodysplasia verruciformis (EV). The severe form of EV is characterized by HPV-5-induced PV-like lesions, multiple skin cancers, and usually depressed cell-mediated immunity. The picture seen in one of our renal allograft recipients recalls this severe form of EV. HPV-5, until now, has been found only in EV patients. The role of this potentially oncogenic virus in skin cancers which are known to occur with increased frequency in immunosuppressed renal allograft recipients must be determined.