Altered Saturated and Monounsaturated Plasma Phospholipid Fatty Acid Profiles in Adult Males with Colon Adenomas.
Altered Saturated and Monounsaturated Plasma Phospholipid Fatty Acid Profiles in Adult Males with Colon Adenomas.
复制标题
患有结肠腺瘤的成年男性的饱和和单不饱和血浆磷脂脂肪酸谱发生改变。
DOI：
10.1158/1055-9965.epi-15-0696
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Fenton,JeniferI
中科院分区：
文献类型：
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作者：
Pickens,CAustin;Lane-Elliot,Ami;Comstock,SarahS;Fenton,JeniferI
背景：脂质代谢和血浆脂肪酸（FA）水平的改变与结直肠癌有关。肥胖和腰围增高会增加患癌前结肠腺瘤的可能性。方法：对126例接受常规结肠镜检查的48 ~ 65岁男性进行静脉血采集。对血浆磷脂（PPL） FAs进行分离、衍生化、气相色谱分析。在调整混杂因素（即年龄、吸烟、WC和体重指数（BMI））后，使用多分式logistic回归确定or和95%置信区间。结果：PPL棕榈酸（PA）与结肠腺瘤的存在呈负相关（P= 0.01）。棕榈油酸（OR, 3.75；P= 0.04）或油酸（OR, 2.92；P= 0.04）每增加一个单位，一个人患腺瘤的可能性就比没有结肠息肉的人高。较高的硬脂酰辅酶a去饱和酶-1 （SCD-1， P= 0.02）和超长链脂肪酸蛋白-6 （ELOVL-6， P= 0.03）的酶活性估计（EAE）与个体患腺瘤的可能性约为无息肉者的1.5倍相关。结论：先前与结直肠癌相关的PPL FAs和eae在腺瘤患者中与无息肉患者相比有显著差异。PPL PA、elaidic酸、SCD-1和ELOVL-6 eae与腺瘤相关，与BMI和WC无关。影响：PPL PA、elaidic酸、SCD-1和ELOVL-6 eae与腺瘤相关，即使在调整了肥胖相关的危险因素后，也可能作为早期结直肠癌风险的新生物标志物。癌症流行病学生物标志物；25 (3);498 - 506。AACR©2015。
Background:Altered lipid metabolism and plasma fatty acid (FA) levels are associated with colorectal cancer. Obesity and elevated waist circumference (WC) increase the likelihood of developing precancerous colon adenomas.Methods:Venous blood was collected from 126 males, ages 48 to 65 years, who received routine colonoscopies. Plasma phospholipid (PPL) FAs were isolated, derivatized, and then analyzed using gas chromatography. ORs and 95% confidence intervals were determined using polytomous logistic regression after adjusting for confounding factors [i.e., age, smoking, WC, and body mass index (BMI)].Results:PPL palmitic acid (PA) was inversely correlated with the presence of colon adenomas (P= 0.01). For each unit increase in palmitoleic acid (OR, 3.75;P= 0.04) or elaidic acid (OR, 2.92;P= 0.04), an individual was more likely to have adenomas relative to no colon polyps. Higher enzyme activity estimates (EAE) of stearoyl-CoA desaturase-1 (SCD-1;P= 0.02) and elongation of very long chain fatty acids protein-6 (ELOVL-6;P= 0.03) were associated with an individual being approximately 1.5 times more likely to have an adenoma compared with no polyps.Conclusions:PPL FAs and EAEs, which have previously been associated with colorectal cancer, are significantly different in those with adenomas when compared with those without polyps. PPL PA, elaidic acid, and SCD-1 and ELOVL-6 EAEs are associated with adenomas independent of BMI and WC.Impact:PPL PA, elaidic acid, and SCD-1 and ELOVL-6 EAEs are associated with adenomas even after adjusting for obesity-related risk factors and may function as novel biomarkers of early colorectal cancer risk.Cancer Epidemiol Biomarkers Prev; 25(3); 498–506. ©2015 AACR.