POSTSYNAPTIC ALPHA-2-NORADRENERGIC RECEPTORS MEDIATE FEEDING INDUCED BY PARAVENTRICULAR NUCLEUS INJECTION OF NOREPINEPHRINE AND CLONIDINE
POSTSYNAPTIC ALPHA-2-NORADRENERGIC RECEPTORS MEDIATE FEEDING INDUCED BY PARAVENTRICULAR NUCLEUS INJECTION OF NOREPINEPHRINE AND CLONIDINE
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DOI：
10.1016/0014-2999(85)90578-3
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
LEIBOWITZ, SF
中科院分区：
文献类型：
--
作者：
GOLDMAN, CK;MARINO, L;LEIBOWITZ, SF
本研究探讨了下丘脑去甲肾上腺素能刺激引起的摄食反应，其介导受体的类型和突触位置。将去甲肾上腺素或α 2受体激动剂可乐定注射入室旁核（PVN）区域的试验显示，在饱足的动物中有强有力的进食反应。通过局部注射α 2-去甲肾上腺素能拮抗剂rauwolscine和育亨宾，以剂量依赖性方式阻断任一激动剂的这种反应。它也被一般拮抗剂酚妥拉明阻断。相反，它不受下丘脑注射α 1-去甲肾上腺素能拮抗剂哌唑嗪和柯宁的影响。这些结果表明，由PVN区域中的去甲肾上腺素能刺激引起的进食是通过α 2型受体介导的。这些α 2受体似乎位于突触后，因为可乐定在诱发进食中的有效性不受先前注射的儿茶酚胺合成抑制剂α-受体的干扰。甲基对酪氨酸
This study examines the feeding response induced by hypothalamic noradrenergic stimulation, in terms of the type and synaptic position of its mediating receptor. Tests with norepinephrine or the .alpha.2 receptor agonist clonidine, injected into the area of the paraventricular nucleus (PVN), revealed a potent feeding response in satiated animals. This response by either agonist was blocked, in a dose-dependent fashion, by local injection of the .alpha.2-noradrenergic antagonists, rauwolscine and yohimbine. It was also blocked by the general antagonist, phentolamine. In contrast, it was unaffected by hypothalamic injection of the .alpha.1-noradrenergic antagonists, prazosin and corynanthine. These results indicate that feeding elicited by noradrenergic stimulation in the region of the PVN is mediated through .alpha.2-type receptors. These .alpha.2 receptors appear to be located postsynaptically, since the effectiveness of clonidine in eliciting eating was undistrubed by prior injection of the catecholamine synthesis inhibitor, .alpha.-methyl-p-tyrosine.