Evidence for the importance of basal ganglia output nuclei in semantic event sequencing: an fMRI study.
Evidence for the importance of basal ganglia output nuclei in semantic event sequencing: an fMRI study.
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基底神经节输出核在语义事件排序中重要性的证据：一项功能磁共振成像研究。
DOI：
10.1016/j.brainres.2005.10.057
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Stern,ChantalE
中科院分区：
文献类型：
--
作者：
Tinaz,Sule;Schendan,HalineE;Schon,Karin;Stern,ChantalE
语义事件排序是提前计划并按时间顺序排列有意义事件的能力。为了研究支持这种能力的神经系统，开发了fMRI图像排序任务。参与者根据图片之间的时间关系，对四张随机呈现的图片进行排序。对照对象辨别任务在语义、视觉空间和运动加工要求上与排序任务相当，但没有排序要求。fMRI显示，与对照任务相比，在图片排序任务中，背外侧前额叶皮层和苍白球内部部分明显激活。研究结果表明，涉及额叶和基底神经节输出核的回路对图像排序很重要，更普遍地说，对事件的顺序排序很重要。这与基底神经节输出核不仅对运动而且对高级认知功能（包括涉及有意义信息的行为）至关重要的观点是一致的。我们认为，在语义事件排序中，额叶和基底神经节输出核之间的相互作用可以概括为包括行为的顺序排序，其中神经表征的选择性更新是关键的计算。
Semantic event sequencing is the ability to plan ahead and order meaningful events chronologically. To investigate the neural systems supporting this ability, an fMRI picture sequencing task was developed. Participants sequenced a series of four pictures presented in random order based on the temporal relationship among them. A control object discrimination task was designed to be comparable to the sequencing task regarding semantic, visuospatial, and motor processing requirements but without sequencing demands. fMRI revealed significant activation in the dorsolateral prefrontal cortex and globus pallidus internal part in the picture sequencing task compared with the control task. The findings suggest that circuits involving the frontal lobe and basal ganglia output nuclei are important for picture sequencing and more generally for the sequential ordering of events. This is consistent with the idea that the basal ganglia output nuclei are critical not only for motor but also for high-level cognitive function, including behaviors involving meaningful information. We suggest that the interaction between the frontal lobes and basal ganglia output nuclei in semantic event sequencing can be generalized to include the sequential ordering of behaviors in which the selective updating of neural representations is the key computation.