A new way to ignite thermogenesis in human adipose tissue.

A new way to ignite thermogenesis in human adipose tissue.
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一种点燃人体脂肪组织生热作用的新方法。

DOI:
10.1038/s41574-020-0390-4
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发表时间:
2020
期刊:
Nature reviews. Endocrinology
影响因子:
--
通讯作者:
Kajimura,Shingo
Kajimura,Shingo
中科院分区:
--
文献类型:
--
作者:
Verkerke,AnthonyRP;Kajimura,Shingo

文献摘要

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产热脂肪组织是多余能量的代谢库,是治疗肥胖症和2型糖尿病的有希望的靶点。然而,在激活人类产热脂肪组织方面存在障碍。一项新的研究开发了一种利用人类米色脂肪组织的药物筛选平台,并确定了非经典激活剂。
Thermogenic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes mellitus. However, hurdles exist in activating thermogenic adipose tissue in humans. A new study developed a drug screening platform utilizing human beige adipose tissue and identified non-canonical activators.