Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells.
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells.
复制标题
肌球蛋白轻链激酶抑制剂对大鼠嗜铬细胞瘤 PC12h 细胞分泌儿茶酚胺的影响。
DOI：
10.1016/0006-291x(87)90357-3
复制
发表时间：
1987
影响因子：
3.1
通讯作者：
H. Hidaka
中科院分区：
文献类型：
--
作者：
T. Nagatsu;H. Suzuki;K. Kiuchi;M. Saitoh;H. Hidaka
高 K+ (50 mM) 从大鼠嗜铬细胞瘤 PC12h 细胞中释放的多巴胺被肌球蛋白轻链激酶 (ML-9) 的特异性抑制剂抑制，呈剂量依赖性。肌球蛋白轻链激酶抑制剂还特异性抑制肌球蛋白轻链激酶对 20 KDa 蛋白的磷酸化。肌球蛋白轻链激酶可能在大鼠嗜铬细胞瘤细胞儿茶酚胺的释放反应中起刺激作用。
Release of dopamine from rat pheochromocytoma PC12h cells by high K+(50 mM) was inhibited by a specific inhibitor of myosin light-chain kinase (ML-9) dose-dependently. The myosin light-chain kinase inhibitor also specifically inhibited the phosphorylation of a 20 KDa protein by myosin light-chain kinase. Myosin light chain kinase may play a stimulatory role in the release reaction of catecholamines from the rat pheochromocytoma cells.