EzrA: a spectrin-like scaffold in the bacterial cell division machinery.
EzrA: a spectrin-like scaffold in the bacterial cell division machinery.
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DOI：
10.15698/mic2015.02.187
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发表时间：
2015-01-15
期刊：
影响因子：
--
通讯作者：
Lewis R
中科院分区：
文献类型：
--
作者：
Cleverley R;Lewis R
在鉴定分裂体的成分方面已经取得了很大进展，分裂体是承担细菌细胞分裂关键过程的蛋白质组装。然而，膜两边高度相互依赖的过程在分裂过程中如何协调是一个重大的悬而未决的问题。细胞外细胞壁的降解和合成如何与微管蛋白同系物FtsZ从细胞内部驱动的胞质分裂和膜分裂相协调？这种协调的一个可能的关键媒介是膜蛋白Ezra，因为它与FtsZ和合成肽聚糖的青霉素结合蛋白(PBPs)相互作用。克莱维利等人。[Natural Communications(2014)5,5421]最近解决了枯草杆菌Ezra细胞质结构域的晶体结构，这表明Ezra在分裂组中扮演着重要的支架角色。这种结构类似于真核细胞骨架的幽灵蛋白，它将细胞骨架中的肌动蛋白细丝连接起来，并将肌动蛋白细胞骨架与膜结合的整合素蛋白连接起来。
Much progress has been made in identifying the components of the divisome, the assembly of proteins that undertakes the vital process of cell division in bacteria. However, how the highly interdependent processes on either side of the membrane are coordinated during division is a major unresolved question. How is the degradation and synthesis of the cell wall on the outside of the cell coordinated with cytokinesis and membrane fission, which are driven from the inside of the cell by the tubulin homologue FtsZ? A possible key mediator of such coordination is the membrane protein EzrA, as it interacts both with FtsZ and the penicillin binding proteins (PBPs) that synthesize peptidoglycan. Cleverley et al. [Nature Communications (2014) 5, 5421] have recently solved the crystal structure of the cytoplasmic domain of B. subtilis EzrA, which points to an important scaffolding role for EzrA in the divisome. The structure resembles the eukaryotic, cytoskeletal spectrin proteins, which link actin filaments in the cytoskeleton and also connect the actin cytoskeleton to membrane-bound integrin proteins.