Modulator property of the intrinsic cortical projection from layer 6 to layer 4
Modulator property of the intrinsic cortical projection from layer 6 to layer 4
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DOI：
10.3389/neuro.06.003.2009
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发表时间：
2009-01-01
影响因子：
3
通讯作者：
Sherman, S. Murray
中科院分区：
文献类型：
--
作者：
Lee, Charles C.;Sherman, S. Murray
感觉新皮层的第4层接受来自丘脑、皮层内和皮质来源的广泛会聚输入。然而，这些途径中的大多数的相对信息承载作用仍然在很大程度上不确定。在这里，我们表明，从第6层到第4层的皮质内投影表现出的生理特性，这是一致的调制器的作用。使用体外切片制备的听觉和体感皮层，我们发现，电刺激或光刺激层6 elaborates一个延长的去极化反应，这是由于组1代谢型谷氨酸受体的激活。这些结果补充了层6至层4通路的已知生理特性，并进一步表明该通路不是信息流的主要管道，而是作为皮质活动的调制器。
Layer 4 of the sensory neocortex receives widespread convergent inputs from thalamic, intracortical, and corticocortical sources. Yet, the relative information bearing roles for most of these pathways remain largely undefined. Here we show that the intracortical projections from layer 6 to layer 4 exhibit a physiological property that is consistent with a modulator role. Using in vitro slice preparations of the auditory and somatosensory cortices, we found that electrical stimulation or photostimulation of layer 6 elicits a prolonged depolarizing response that is attributable to the activation of group 1 metabotropic glutamate receptors. These results complement the known physiological properties of the layer 6 to layer 4 pathway, and further suggest that this pathway is not a principle conduit for information flow, but rather acts as a modulator of cortical activity.