Detection of m6A-associated SNPs as potential functional variants for coronary artery disease
Detection of m6A-associated SNPs as potential functional variants for coronary artery disease
复制标题
检测 m6A 相关 SNP 作为冠状动脉疾病的潜在功能变异
DOI：
10.2217/epi-2018-0007
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发表时间：
2018-10-01
期刊：
影响因子：
3.8
通讯作者：
Zhang, Huan
中科院分区：
文献类型：
--
作者：
Mo, Xing-Bo;Lei, Shu-Feng;Zhang, Huan
目的：探讨m(6) a单核苷酸多态性（snp）在冠心病（CAD）发病中的作用。方法：我们在大约185,000例病例和对照中检测了m(6)A-SNPs与CAD的关联，并进一步进行了eQTL和差异表达分析来支持鉴定的m(6)A-SNPs。结果：在检测到的4390 m(6)个a - snp中，304个似乎与CAD相关（p < 0.05）。SNP rs12286在全基因组水平上与CAD显著相关（p = 4.5x10(-9)）。预计rs12286会影响m(6)A甲基化，并有可能改变调节基序的结合，这可能反过来调节ADAMTS7的表达（p = 1.26x10(-8)）。结论：本研究发现了大量与cad相关的m(6) a - snp，并证明了所鉴定的snp的潜在功能。
Aim: To investigate the effects of m(6)A-single nucleotide polymorphisms (SNPs) on coronary artery disease (CAD). Methods: We examined the association of m(6)A-SNPs with CAD in about 185,000 cases and controls and further performed eQTL and differential expression analyses to support the identified m(6)A-SNPs. Results: Among the 4390 m(6)A-SNPs detected, 304 seemed to be associated with CAD (p < 0.05). SNP rs12286 was significantly associated with CAD at genome-wide level (p = 4.5x10(-9)). rs12286 was predicted to influence m(6)A methylation and have the potential to alter regulatory motifs binding, which may in turn regulate the expression of ADAMTS7 (p = 1.26x10(-8)). Conclusion: The present study found plenty of CAD-associated m(6)A-SNPs and demonstrated the potential functionality of the identified SNPs.