Fullerene C60 as a multifunctional system for drug and gene delivery
Fullerene C60 as a multifunctional system for drug and gene delivery
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DOI：
10.1039/c1nr10783f
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发表时间：
2011-01-01
期刊：
影响因子：
6.7
通讯作者：
Prato, Maurizio
中科院分区：
文献类型：
--
作者：
Montellano, Alejandro;Da Ros, Tatiana;Prato, Maurizio
富勒烯家族，特别是C-60，在过去的25年里，在包括生物和生物医学领域在内的广泛领域中具有前瞻性的应用，使科学界感到高兴。已经使用水溶性C-60衍生物探索了几种生物医学用途。然而，富勒烯用于药物递送的应用仍处于早期发展阶段。设计和合成能够穿过细胞膜并有效递送活性分子的多功能和多模态C-60系统是一个涉及多学科策略的吸引人的挑战。在过去的几年里出现了有希望的结果，使富勒烯再次成为人们感兴趣的前沿。在这里，这一新兴领域的最新技术水平，并与一些最具代表性的例子说明。
The fullerene family, and especially C-60, has delighted the scientific community during the last 25 years with perspective applications in a wide variety of fields, including the biological and the biomedical domains. Several biomedical uses have been explored using water-soluble C-60-derivatives. However, the employment of fullerenes for drug delivery is still at an early stage of development. The design and synthesis of multifunctionalized and multimodal C-60 systems able to cross the cell membranes and efficiently deliver active molecules is an attracting challenge that involves multidisciplinary strategies. Promising results have emerged in the last years, bringing fullerenes again to the front of interest. Herein, the state of the art of this emerging field is presented and illustrated with some of the most representative examples.