FLUVIRUCIN-A1, FLUVIRUCIN-A2, FLUVIRUCIN-B1, FLUVIRUCIN-B2, FLUVIRUCIN-B3, FLUVIRUCIN-B4, AND FLUVIRUCIN-B5, NEW ANTIBIOTICS ACTIVE AGAINST INFLUENZA-A VIRUS .1. PRODUCTION, ISOLATION, CHEMICAL-PROPERTIES AND BIOLOGICAL-ACTIVITIES
FLUVIRUCIN-A1, FLUVIRUCIN-A2, FLUVIRUCIN-B1, FLUVIRUCIN-B2, FLUVIRUCIN-B3, FLUVIRUCIN-B4, AND FLUVIRUCIN-B5, NEW ANTIBIOTICS ACTIVE AGAINST INFLUENZA-A VIRUS .1. PRODUCTION, ISOLATION, CHEMICAL-PROPERTIES AND BIOLOGICAL-ACTIVITIES
复制标题
DOI：
10.7164/antibiotics.44.733
复制
发表时间：
1991-07-01
影响因子：
3.3
通讯作者：
OKI, T
中科院分区：
文献类型：
--
作者：
NARUSE, N;TENMYO, O;OKI, T
5株未鉴定的放线菌产生了一系列新的抗病毒抗生素，其独特的2，6-二烷基-10-乙基-3（或9）-羟基-13-十三烷内酰胺环被3-氨基-3，6-双脱氧-L-塔罗糖或3-氨基-3，6-双脱氧-L-甘露糖（L-真菌胺）取代。 通过细胞病变效应降低试验，抗生素组分对Madin达比犬肾细胞中的流感病毒A型维多利亚株感染表现出有效的抑制活性。
Five unidentified actinomycete strains produced a series of novel antiviral antibiotics which have a unique 2,6-dialkyl-10-ethyl-3(or 9)-hydroxy-13-tridecanelactam nucleus substituted with 3-amino-3,6-dideoxy-L-talose or 3-amino-3,6-dideoxy-L-mannose(L-mycosamine). The antibiotic components exhibited potent inhibitory activity against influenza virus type A Victoria strain infection in Madin Darby canine kidney cells by the cytopathic effect reduction assay.