Iron deficiency anemia increases nitric oxide production in healthy adolescents
Iron deficiency anemia increases nitric oxide production in healthy adolescents
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DOI：
10.1007/s00277-001-0409-4
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发表时间：
2002-01-01
影响因子：
3.5
通讯作者：
Cha, YN
中科院分区：
文献类型：
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作者：
Choi, JW;Pai, SH;Cha, YN
为探讨缺铁和补铁对一氧化氮(NO)产生的影响，对369名14~19岁女性的血清铁标志物、血清硝酸盐和亚硝酸盐(NOx)浓度、网织红细胞成熟度指数(RMI)和血清转铁蛋白受体(STfR)水平进行了测定。用流式细胞仪分析RMI，用酶免疫法测定sTfR浓度，用Griess反应测定血清NOx水平。铁耗竭期受试者的NOx浓度显著高于健康对照组。随着缺铁性贫血的进展，NOx浓度逐渐升高，当受试者出现明显的缺铁性贫血时，NOx浓度是健康对照组的三倍。特别是，严重缺铁性贫血(HB)患者的NOx浓度要高出7.5倍
To investigate the influence of iron deficiency and iron supplementation on nitric oxide (NO) production, we measured serum iron markers, serum nitrate and nitrite (NOx) concentrations, reticulocyte maturity index (RMI), and serum transferrin receptor (sTfR) levels in 369 females aged 14-19 years. RMI was analyzed by flow cytometry, sTfR concentrations were measured by enzyme immunoassay, and serum NOx levels were tested by the Griess reaction. NOx concentrations of the subjects in iron depletion phase were significantly higher than those of healthy controls. NOx concentrations increased gradually as iron deficiency progressed and were threefold higher than for the healthy controls, when the subjects attained a frank iron deficiency anemia. In particular, the NOx concentrations were 7.5-fold higher in the patients with severe iron deficiency anemia (Hb