MILK PRECIPITINS, CIRCULATING IMMUNE-COMPLEXES, AND IGA DEFICIENCY
MILK PRECIPITINS, CIRCULATING IMMUNE-COMPLEXES, AND IGA DEFICIENCY
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DOI：
10.1073/pnas.75.7.3387
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
DAY, NK
中科院分区：
文献类型：
--
作者：
CUNNINGHAMRUNDLES, C;BRANDEIS, WE;DAY, NK
对22例选择性免疫球蛋白A缺乏症患者进行了血清沉淀素对牛奶、牛和胎牛血清及循环免疫复合物的影响研究。59%的人有循环免疫复合物，50%的人有乳沉淀，23%的人有牛血清沉淀，13%的人有胎牛血清沉淀。所有对牛奶或牛或胎牛血清有沉淀抗体的患者均有循环免疫复合物，沉淀滴度与循环免疫复合物的数量相关。在1名iga缺乏患者喝下100毫升牛奶后，对连续血清样本的研究显示，在60分钟内循环中存在酪蛋白，在120分钟内出现免疫复合物的数量增加。在人类中，IgA系统可能为免疫原从胃肠道的吸收提供了一个主要的屏障。
Twenty-two patients with selective Ig[immunoglobulin]A deficiency were studied for the presence of serum precipitins to bovine milk, bovine and fetal calf serum and circulating immune complexes. Fifty-nine percent had circulating immune complexes, 50% had milk precipitins, 23% had precipitins to bovine serum and 13% had precipitins to fetal calf serum. All patients with precipitating antibodies against milk or against bovine or fetal calf serum had circulating immune complexes and the precipitin titers correlated with the amount of circulating immune complexes. After 1 IgA-deficient patient drank 100 ml of milk, studies of sequential serum samples showed the presence of casein in the circulation at 60 min and the appearance of increasing amounts of immune complexes for 120 min. In humans the IgA system may provide a major barrier to asborption of immunogens from the gastrointestinal tract.