Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis
Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis
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DOI：
10.1016/j.bbrc.2008.02.134
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发表时间：
2008-05-09
影响因子：
3.1
通讯作者：
Vindis, Cecile
中科院分区：
文献类型：
--
作者：
Ingueneau, Cecile;Huynh-Do, Uyen;Vindis, Cecile
氧化低密度脂蛋白（oxLDL）诱导的血管细胞凋亡可能参与斑块的不稳定和破裂。小窝蛋白-1已成为在动脉粥样硬化中发挥作用的几个信号转导通路和过程的重要调节剂。在这项研究中，我们研究了caveolin-1在调节oxLDL诱导的血管平滑肌细胞（VSMC）的Ca 2+信号和凋亡中的潜在作用。表达小窝蛋白-1的细胞对oxLDL诱导的凋亡更敏感，这与增强的Ca 2+进入和促凋亡事件相关。此外，小窝蛋白-1沉默小干扰RNA降低oxLDL处理后的凋亡细胞的水平。这些研究结果提供了新的见解小窝蛋白-1在调节oxLDL诱导的血管细胞凋亡及其对斑块不稳定性的贡献的潜在作用。(c)2008年爱思唯尔公司All rights reserved.
Oxidized low-density lipoprotein (oxLDL)-induced apoptosis of vascular cells may participate to plaque instability and rupture. Caveolin-1 has emerged as an important regulator of several signal transduction pathways and processes that play a role in atherosclerosis. In this study we examined the potential role of caveolin-1 in the regulation of oxLDL-induced Ca2+ signaling and apoptosis in vascular smooth muscle cells (VSMC). Cells expressing caveolin-1 were more susceptible to oxLDL-induced apoptosis, and this was correlated with enhanced Ca2+ entry and pro-apoptotic events. Moreover, caveolin-1 silencing by small interfering RNA decreased the level of apoptotic cells after oxLDL treatment. These findings provide new insights about the potential role of caveolin-1 in the regulation of oxLDL-induced apoptosis in vascular cells and its contribution to the instability of the plaque. (c) 2008 Elsevier Inc. All rights reserved.