Normative Study of the Binaural Interaction Component of the Human Auditory Brainstem Response as a Function of Interaural Time Differences.
Normative Study of the Binaural Interaction Component of the Human Auditory Brainstem Response as a Function of Interaural Time Differences.
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DOI：
10.1097/aud.0000000000000964
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Tollin DJ
中科院分区：
文献类型：
--
作者：
Sammeth CA;Greene NT;Brown AD;Tollin DJ
从双耳诱发的听性脑干反应（ABR）中减去左右耳单耳ABR之和，得到ABR的双耳交互分量（BIC）。结果是小但突出的负峰（在此称为"DN 1"），指示比总和ABR更小的双耳，其发生在波V的潜伏期或其滚降斜率周围。BIC已被提出作为双耳处理能力的生物标志物具有诊断价值;然而，关于BIC测量在人类受试者中的可靠性存在相互矛盾的报告。本研究的目的是：1）检查听力正常年轻人中BIC的患病率，2）确定双耳时间差（ITD）对BIC的影响，3）检查BIC与行为ITD辨别敏锐度之间的任何关系。受试者为40名听力正常的成年人（20名男性，20名女性），年龄21至48岁，无耳科或神经系统疾病史。以颈后（第7颈椎附近）为基准，从高前额（Fz）电极记录中线ABR，以Fpz（低前额）为基础。ABR也记录了一个传统的耳垂参考比较中线的结果。刺激为90 dB peSPL双相短声。对于BIC测量，刺激在块中呈现为交错的右单耳、左单耳和双耳刺激，每个条件具有2000+呈现。对每个分析波形总共8000+个刺激的四次测量进行平均。在ITD = 0（同时双侧）和ITD为± 500 μ s和± 750 μ s时测量BIC。受试者分别进行了偏侧化任务，使用相同的刺激，以确定ITD的歧视阈值。40名受试者中有39名在ITD = 0 μ s时至少在两次测量中的一次测量中获得了可识别的BIC DN1，但在单次测量中或随着ITD增加，在较少数量的受试者中观察到了BIC DN1。BIC最常在受试者放松或睡眠时出现，而当他们坐立不安或报告颈部紧张时则不太常见，这表明肌源性活动可能是干扰BIC测量的一个因素。随着ITD的增加，平均BIC潜伏期系统性增加，平均BIC振幅趋于降低。然而，在所有受试者中，BIC的振幅或潜伏期与行为ITD阈值之间没有显著关系。与先前的研究一致，BIC的测量是耗时的，并且在清醒的正常听力受试者中有时难以获得BIC。因此，BIC将继续具有有限的临床实用性，除非可以识别产生更稳健响应的刺激参数和测量技术。尽管如此，ITD对BIC特征的调制支持ABR BIC索引双耳脑干处理方面的概念，因此可以证明在选定的研究应用中是有用的，例如在预期具有异常双耳信号处理能力的人群的检查中。
The binaural interaction component (BIC) of the auditory brainstem response (ABR) is obtained by subtracting the sum of the monaural right and left ear ABRs from the binaurally evoked ABR. The result is a small but prominent negative peak (herein called “DN1”), indicating a smaller binaural than summed ABR, that occurs around the latency of wave V or its roll-off slope. The BIC has been proposed to have diagnostic value as a biomarker of binaural processing abilities; however, there have been conflicting reports regarding the reliability of BIC measures in human subjects. The objectives of the current study were to: 1) examine prevalence of BIC across a large group of normal-hearing young adults, 2) determine effects of interaural time differences (ITDs) on BIC, and 3) examine any relationship between BIC and behavioral ITD discrimination acuity. Subjects were 40 normal-hearing adults (20 male, 20 female), aged 21 to 48, with no history of otologic or neurologic disorders. Midline ABRs were recorded from electrodes at high forehead (Fz) referenced to the nape of the neck (near the 7th cervical vertebra), with Fpz (low forehead) as the ground. ABRs were also recorded with a conventional earlobe reference for comparison to midline results. Stimuli were 90 dB peSPL biphasic clicks. For BIC measurements, stimuli were presented in a block as interleaved right monaural, left monaural, and binaural stimuli with 2000+ presentations per condition. Four measurements were averaged for a total of 8000+ stimuli per analyzed waveform. BIC was measured for ITD = 0 (simultaneous bilateral) and for ITDs of ± 500 μs and ± 750 μs. Subjects separately performed a lateralization task, using the same stimuli, to determine ITD discrimination thresholds. An identifiable BIC DN1 was obtained in 39 of 40 subjects at ITD = 0 μs in at least one of two measurement sessions, but was seen in lesser numbers of subjects in a single session or as ITD increased. BIC was most often seen when a subject was relaxed or sleeping, and less often when they fidgeted or reported neck tension, suggesting myogenic activity as a possible factor in disrupting BIC measurements. Mean BIC latencies systematically increased with increasing ITD, and mean BIC amplitudes tended to decrease. However, across subjects there was no significant relationship between the amplitude or latency of the BIC and behavioral ITD thresholds. Consistent with previous studies, measurement of the BIC was time consuming and a BIC was sometimes difficult to obtain in awake normal-hearing subjects. The BIC will thus continue to be of limited clinical utility unless stimulus parameters and measurement techniques can be identified that produce a more robust response. Nonetheless, modulation of BIC characteristics by ITD supports the concept that the ABR BIC indexes aspects of binaural brainstem processing and thus may prove useful in selected research applications, e.g. in the examination of populations expected to have aberrant binaural signal processing ability.