After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance
After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance
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DOI：
10.1016/j.physbeh.2008.01.008
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发表时间：
2008-06-09
影响因子：
2.9
通讯作者：
Hoebel, Bartley G.
中科院分区：
文献类型：
--
作者：
Avena, Nicole M.;Bocarsly, Miriam E.;Hoebel, Bartley G.
暴饮暴食可能会以类似于滥用药物的方式激活神经通路，导致相关的依赖迹象。目前的实验测试了暴饮暴食蔗糖然后禁食的大鼠是否表现出阿片类戒断的迹象。大鼠被剥夺12小时，然后12小时摄入10%的蔗糖溶液和食物28天，然后禁食36小时。与同样剥夺自由饮食的大鼠组相比，这些动物在暴露在高架正迷宫手臂上的时间更少，这表明他们有焦虑。微透析显示细胞外乙酰胆碱增加，伏隔核壳内多巴胺释放减少。这些结果似乎并不是由于低血糖所致。研究结果表明，暴食蔗糖和食物，然后禁食会导致焦虑和伏隔素、多巴胺和乙酰胆碱平衡的改变。这与纳洛酮的效果相似，提示阿片类戒断。这可能是导致某些饮食失调的一个因素。(C)2008 Elsevier Inc.保留所有权利。
Bingeing on sugar may activate neural pathways in a manner similar to taking drugs of abuse, resulting in related signs of dependence. The present experiments test whether rats that have been bingeing on sucrose and then fasted demonstrate signs of opiate-like withdrawal. Rats were maintained on 12-h deprivation followed by 12-h access to a 10% sucrose solution and chow for 28 days, then fasted for 36 h. These animals spent less time on the exposed arm of an elevated plus-maze compared with a similarly deprived ad libitum chow group, suggesting anxiety. Microdialysis revealed a concomitant increase in extracellular acetylcholine and decrease in dopamine release in the nucleus accumbens shell. These results did not appear to be due to hypoglycemia. The findings suggest that a diet of bingeing on sucrose and chow followed by fasting creates a state that involves anxiety and altered accumbens dopamine and acetylcholine balance. This is similar to the effects of naloxone, suggesting opiate-like withdrawal. This may be a factor in some eating disorders. (C) 2008 Elsevier Inc. All rights reserved.