Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN).
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儿科急性白血病治疗期间的急性和慢性肾损伤：来自白血病电子记录网络 (LEARN) 的报告。
DOI：
10.1002/pbc.30696
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发表时间：
2023
影响因子：
3.2
通讯作者：
Miller,TamaraP
中科院分区：
文献类型：
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作者：
Hsiao,Wendy;Li,Yimei;Getz,Kelly;Cao,Lusha;Krause,Edward;Ramos,Mark;Lee,Judy;Gramatges,MariaMonica;Rabin,KarenR;Scheurer,MichaelE;Aplenc,Richard;Denburg,Michelle;Miller,TamaraP
患有急性白血病的儿童肾损伤的风险增加。本研究使用2010年至2018年三家中心的电子健康记录数据，回顾性描述了急性淋巴细胞或髓性白血病（ALL，AML）儿童的急性肾损伤（阿基）和慢性肾脏病（CKD）患病率，使用不良事件通用术语标准（CTCAE）和肾脏病改善全球结局（KDIGO）定义。使用CTCAE，治疗期间阿基为25%（ALL）和32%（AML），而使用KDIGO，AKI为84%（ALL）和74%（AML）。CKD患病率较低，为1级/2期。需要进一步的研究来最佳地定义急性白血病的肾损伤。
Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.