Contribution of rod and cone pathways to the dark-adapted electroretinogram (ERG) b-wave following retinal degeneration in RCS rats.
Contribution of rod and cone pathways to the dark-adapted electroretinogram (ERG) b-wave following retinal degeneration in RCS rats.
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RCS 大鼠视网膜变性后视杆细胞和视锥细胞通路对暗适应视网膜电图 (ERG) b 波的贡献。
DOI：
10.1016/j.visres.2004.05.020
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sauve,Y
中科院分区：
文献类型：
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作者：
Pinilla,I;Lund,RD;Sauve,Y
虽然RCS大鼠被广泛用作进行性光感受器丧失的模型，但尚不清楚相对视杆和视锥功能如何随年龄变化。采用双闪光ERG技术分离视杆和视锥b波。与视锥细胞不同的是，视杆细胞从未达到正常的功能成熟水平，ERG b波从主要由视杆细胞驱动转变为74天龄时纯粹由视锥细胞驱动，在这一点上，b波逐渐被持续到180天的负STR样(暗点阈值反应)波所取代。双闪光通常会取消这一波，并揭开b波的面纱。
Although the RCS rat is widely used as a model of progressive photoreceptor loss, it is unclear how the relative rod and cone functions change with age. Rod and cone b-waves were isolated using a double flash ERG paradigm. In contrast to cones, rods never reached normal functional maturity levels, and the ERG b-wave changed from being predominantly rod-driven to being purely cone-driven by age 74 days, at which point, b-waves were progressively replaced by negative STR-like (scotopic threshold response) waves that persisted up to age 180 days. A double flash commonly abolished this wave and unveiled a b-wave.