OCT Angiography and En Face OCT Reflectance Aid in Monitoring Subclinical Inflammation in Serpiginous Choroidopathy.
OCT Angiography and En Face OCT Reflectance Aid in Monitoring Subclinical Inflammation in Serpiginous Choroidopathy.
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OCT 血管造影和 En Face OCT 反射有助于监测匍匐性脉络膜病变的亚临床炎症。
DOI：
10.1155/2020/8897394
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Llop,Stephanie
中科院分区：
文献类型：
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作者：
Wilkins,CarlS;AndradeRomo,JorgeS;Chui,TocoYP;Rosen,RichardB;Llop,Stephanie
导论.我们报告一例伴发新的OCTA和面部OCT反射率检查结果的匍匐性脉络膜病变（SC），这有助于识别亚临床疾病进展。正面OCT反射图像显示，在多模态成像上，受累和未受累视网膜的病变边缘处存在视网膜外小管（ORT）。OCTA结果表明，在病变边界以外的"正常"视网膜中，脉络膜毛细血管的脱落是可变的，这在标准成像上是不可见的，并且在PRT之外显示了清晰的过渡区。这是第一个在OCTA上发现的脉络膜毛细血管萎缩的报告，而不是在传统的多模态成像中发现的。仅通过OCTA可见的血管损伤可能有助于表征炎症的分布，有助于监测传统成像无法显示的抑制，这可能会威胁中央黄斑。ORT在SC表明死亡和重组的外部段的功能障碍的脉络膜毛细血管和RPE，以及用于划分区域的慢性或陈旧性炎症，支持的假设，脉络膜毛细血管是炎症的主要网站在SC。基于这些研究结果，我们建议OCTA对所有患者的匍匐性脉络膜病变，以监测潜在的炎症状态，并帮助确定免疫抑制阈值。
Introduction. We present a case of serpiginous choroidopathy (SC) with novel OCTA and en face OCT reflectance findings which help identify subclinical disease progression.Case Presentation. En face OCT reflectance images demonstrated outer retinal tubules (ORT) at the serpiginous lesion margins of affected and unaffected retina on multimodal imaging. OCTA findings demonstrate variable dropout of choriocapillaris in “normal” retina beyond lesion borders which was not visible on standard imaging and which demonstrated a clear transition zone beyond the ORT.Discussion. This is the first report of choriocapillaris atrophy identified on OCTA not identified on traditional multimodal imaging in serpiginous choroidopathy. Damage to vasculature only visible with OCTA may help characterize the distribution of inflammation, aiding in monitoring of suppression not illustrated by traditional imaging and which may threaten the central macula. ORT in SC suggest death and reorganization of outer segments from dysfunction of the choriocapillaris and RPE, as well as serve to demarcate the area of chronic or old inflammation, supporting the hypothesis that the choriocapillaris is the primary site of inflammation in SC. Based on these findings, we recommend OCTA on all patients with serpiginous choroidopathy to monitor underlying state of inflammation and help determine immunosuppressive threshold.