The emerging role of exosomes in survivin secretion.
The emerging role of exosomes in survivin secretion.
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DOI：
10.14670/hh-30.43
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发表时间：
2015-01
影响因子：
2
通讯作者：
Wall NR
中科院分区：
文献类型：
--
作者：
Khan S;Bennit HF;Wall NR
肿瘤微环境在癌症生物学中起着不可或缺的作用，参与肿瘤的发生、发展和对治疗的反应。肿瘤细胞自身释放的因子有助于创造一个对肿瘤有利但有时有害的环境。存活素是凋亡抑制因子（IAP）蛋白家族的关键成员之一，已显示其存在于细胞质、线粒体、细胞核中，最近还存在于细胞外空间中，通过称为外泌体的小膜结合囊泡转运。外泌体由造血细胞、非造血细胞、肿瘤细胞和非肿瘤细胞分泌，穿梭必需分子如蛋白质、RNA和microRNA，所有这些被认为对于细胞-细胞和细胞-细胞外通讯都是重要的。在这篇综述中，我们讨论了外泌体Survivin及其在修饰肿瘤微环境中的作用。
The tumor microenvironment plays an integral part in the biology of cancer, participating in tumor initiation, progression, and response to therapy. Factors released by tumor cells themselves contribute in creating an environment mostly favorable but sometimes detrimental to the tumor. Survivin, one of the key members of the inhibitor of apoptosis (IAP) family of proteins, has been shown in the cytoplasm, mitochondria, nucleus, and most recently in the extracellular space, transported via small membrane bound vesicles called exosomes. Exosomes are secreted from hematopoietic, non-hematopoietic, tumor, and nontumor cells, shuttling essential molecules such as proteins, RNAs, and microRNAs, all believed to be important for cell-cell and cell-extracellular communication. In this review, we discuss exosomal Survivin and its role in modifying the tumor microenvironment.