Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002
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DOI：
10.1007/s00251-003-0571-z
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发表时间：
2003-07-01
期刊：
影响因子：
3.2
通讯作者：
Wain, H
中科院分区：
文献类型：
--
作者：
Marsh, SGE;Parham, P;Wain, H
2002年5月在加拿大维多利亚举行的世卫组织HLA系统因子命名委员会会议上，决定成立一个小组委员会，协调编码杀伤细胞免疫球蛋白样受体（KIR）的基因等位基因的命名（Marsh et al. 2002）。这些基因编码在19号染色体（19q13.4）上，具有不同程度的多态性。由KIR基因编码的受体由自然杀伤细胞（NK）和一部分T细胞表达，其中一些受体已被证明对HLA I类分子的决定因子具有特异性。KIR的细胞外配体结合部分由两个或三个免疫球蛋白样结构域组成。在维多利亚举行的讨论是在英国剑桥举行的NK多态性会议（2001年7月27日至29日）上对KIR命名法的进一步讨论。此外，国际免疫学会联合会（IUIS）还要求提供KIR基因表达蛋白产物的标准化命名法。
During discussion at the WHO Nomenclature Committee for Factors of the HLA System meeting in Victoria, Canada in May 2002, it was decided to form a subcommittee to co-ordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors KIR) (Marsh et al. 2002). These genes are encoded on chromosome 19 (19q13.4) and have varying degrees of polymorphism. The receptors encoded by the KIR genes are expressed by natural killer (NK) cells and a subset of T cells and some of them have been shown to have specificity for determinants of HLA class I molecules. The extracellular ligand-binding part of KIR consists of two or three immunoglobulin-( Ig-) like domains. The discussions which took place in Victoria are further to earlier discussions on KIR nomenclature at the NK Polymorphism meeting ( 27 - 29 July 2001) in Cambridge, UK. In addition a request has been made by the International Union of Immunological Societies (IUIS) to provide a standardised nomenclature for the expressed protein products of the KIR genes.