circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426
circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426
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DOI：
10.1016/j.bbrc.2021.03.020
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发表时间：
2021-03-13
影响因子：
3.1
通讯作者：
Liang, Zhiqing
中科院分区：
文献类型：
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作者：
Chen, Zhen;Ling, Kaijian;Liang, Zhiqing
环状RNA（circRNA）已被证明与宫颈癌（CC）的发生和发展有关。在本研究中，我们的目的是研究hsa_circ_0000069（circ 0000069）对CC的促肿瘤作用及其作用机制。我们发现circ 0000069在CC细胞和组织中上调，并且N6-甲基腺苷（m6 A）修饰保持circ 0000069的稳定性。功能获得和丧失试验显示，circ 0000069促进CC细胞增殖和迁移。miR-4 426特异性结合circ 0000069并介导其在CC发育中的功能。总之，circ 0000069上调部分归因于m6 A修饰，其通过在CC中海绵化miR-4 426促进细胞增殖和迁移。(c)2021爱思唯尔公司All rights reserved.
Circular RNAs (circRNAs) have been shown to be associated with the occurrence and development of cervical cancer (CC). In the present study, we aimed to investigate the tumor-promoting effect of hsa_circ_0000069 (circ0000069) on CC and the mechanisms underlying its effect. We found that circ0000069 was upregulated in CC cells and tissues, and that N6-methyladenosine (m6A) modification maintained circ0000069 stability. Gain-and loss-of-function assays revealed that circ0000069 promoted CC cell proliferation and migration. miR-4 426 specifically binds circ0000069 and mediates its functions in CC development. In conclusion, circ0000069 was upregulated partially due to m6A modification, which promoted cell proliferation and migration via sponging miR-4 426 in CC.(c) 2021 Elsevier Inc. All rights reserved.