Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response.
Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response.
复制标题
DOI：
10.14336/ad.2021.0830
复制
发表时间：
2022-04
影响因子：
7.4
通讯作者：
Raju RP
中科院分区：
文献类型：
--
作者：
Chu X;Subramani K;Thomas B;Terry AV Jr;Fulzele S;Raju RP
研究表明，年轻生物体血液中的因子可以使老年生物体恢复活力。利用异时共生模型的研究进一步强化了幼年因子可以使老年系统恢复活力的假设。我们试图确定幼年血浆衍生因子对老年小鼠失血性休克损伤后结局的影响。我们发现，青春期前（年轻）小鼠遭受失血性休克存活了很长一段时间，在没有液体复苏，与成熟或老年小鼠相比。为了进一步了解损伤消退的成熟依赖性机制，将从年轻小鼠血浆中分离的细胞外囊泡给予经历失血性休克的老年小鼠。细胞外囊泡治疗延长了老年小鼠的寿命。该治疗导致肝脏和循环中的氧化应激降低，沿着核因子红细胞因子2相关因子2（Nrf 2）及其靶基因的表达增强，以及转录因子BTB和CNC同源物1（Bach 1）的表达降低。我们建议，血浆因子在幼年小鼠有一个修复作用，在老年小鼠损伤的决议，通过调节Nrf 2/Bach 1轴的抗氧化反应途径。
Studies have shown that factors in the blood of young organisms can rejuvenate the old ones. Studies using heterochronic parabiosis models further reinforced the hypothesis that juvenile factors can rejuvenate aged systems. We sought to determine the effect of juvenile plasma-derived factors on the outcome following hemorrhagic shock injury in aged mice. We discovered that pre-pubertal (young) mice subjected to hemorrhagic shock survived for a prolonged period, in the absence of fluid resuscitation, compared to mature or aged mice. To further understand the mechanism of maturational dependence of injury resolution, extracellular vesicles isolated from the plasma of young mice were administered to aged mice subjected to hemorrhagic shock. The extracellular vesicle treatment prolonged life in the aged mice. The treatment resulted in reduced oxidative stress in the liver and in the circulation, along with an enhanced expression of the nuclear factor erythroid factor 2-related factor 2 (Nrf2) and its target genes, and a reduction in the expression of the transcription factor BTB and CNC homology 1 (Bach1). We propose that plasma factors in the juvenile mice have a reparative effect in the aged mice in injury resolution by modulating the Nrf2/Bach1 axis in the antioxidant response pathway.
影响因子：
7.5
作者：
Ngangan AV;Waring JC;Cooke MT;Mandrycky CJ;McDevitt TC
通讯作者：
McDevitt TC