ASSOCIATION OF PATTERNS OF LABIAL SALIVARY-GLAND INFLAMMATION WITH KERATOCONJUNCTIVITIS SICCA - ANALYSIS OF 618 PATIENTS WITH SUSPECTED SJOGRENS-SYNDROME
ASSOCIATION OF PATTERNS OF LABIAL SALIVARY-GLAND INFLAMMATION WITH KERATOCONJUNCTIVITIS SICCA - ANALYSIS OF 618 PATIENTS WITH SUSPECTED SJOGRENS-SYNDROME
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DOI：
10.1002/art.1780370615
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发表时间：
1994-06-01
影响因子：
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通讯作者：
WHITCHER, JP
中科院分区：
文献类型：
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作者：
DANIELS, TE;WHITCHER, JP
目标。目的：探讨唇唾液腺（LSG）炎症类型与干燥综合征（SS）眼部症状之间的关系。我们将618例疑似SS患者的LSG活检标本分类为局灶性淋巴细胞性涎腺炎（FLS）、其他慢性涎腺炎（CS）或其他诊断。然后，我们确定了原发性SS的其他组成部分，干燥性角膜结膜炎（KCS）与FLS、CS、腮腺弓率和口干的关系。FLS而非CS与KCS的诊断相关（chi(2) = 191, P < 0.0001）。KCS的严重程度与FLS的严重程度直接相关（r = 0.52, P < 0.0001），而与CS无关；FLS患者与腮腺流量呈负相关（r = -0.29），而CS患者与腮腺流量呈负相关（r = -0.03）。口干与KCS有轻微相关性（chi(2) = 5, P = 0.02）。
Objective. To determine the association between patterns of inflammation in labial salivary glands (LSG) and the ocular component of Sjogren's syndrome (SS).Methods. We classified LSG biopsy specimens from 618 patients with suspected SS as showing focal lymphocytic sialadenitis (FLS), other chronic sialadenitis (CS), or other diagnoses. We then determined the association of the other component of primary SS, keratoconjunctivitis sicca (KCS), with FLS, CS, parotid Bow rate, and xerostomia.Results. FLS, rather than CS, was associated with a diagnosis of KCS (chi(2) = 191, P < 0.0001). The severity of KCS correlated directly with the severity of FLS (r = 0.52, P < 0.0001), but not of CS, and correlated inversely with parotid flow rate in those patients who had FLS (r = -0.29), but not in those who had CS (r = -0.03). Xerostomia was marginally associated with KCS (chi(2) = 5, P = 0.02).