Macro-Role of MicroRNA in Gastric Cancer
Macro-Role of MicroRNA in Gastric Cancer
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DOI：
10.1159/000336919
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发表时间：
2012-01-01
影响因子：
2.3
通讯作者：
Malfertheiner, Peter
中科院分区：
文献类型：
--
作者：
Link, Alexander;Kupcinskas, Juozas;Malfertheiner, Peter
胃癌是一种异质性疾病，其发生机制目前尚不清楚。除了遗传和表观遗传机制外，最近发现microRNAs(MiRNAs)通过对抑癌基因和癌基因的转录后调控在胃癌的发生中发挥重要作用。在胃癌中发现了大量非调控的miRNAs，这些miRNAs的生物学意义已经在多个功能实验中得到证实。越来越多的研究表明miRNAs参与了胃癌发生的各个步骤：从胃炎到转移性疾病。MiRNAs良好的生物稳定性为生物标志物的研究开辟了新的领域，在筛查、诊断、预后预测和治疗管理方面具有潜在的临床应用前景。在这篇综述中，我们提供了miRNA生物发生的基本知识，并广泛讨论了miRNAs在胃癌发生中的作用，包括幽门螺杆菌相关的miRNA改变和潜在的翻译临床实施。版权所有(C)2012 S.Karger AG，巴塞尔
Gastric cancer is a heterogeneous disease with currently still unknown mechanisms of development. Besides genetic and epigenetic mechanisms, microRNAs (miRNAs) have recently been discovered as one of the crucial players in gastric carcinogenesis through posttranscriptional regulation of tumor suppressor and oncogenes. A substantial number of deregulated miRNAs have been revealed in gastric cancer and the biological significance of those miRNAs has been confirmed in multiple functional experiments. A growing number of studies suggest involvement of miRNAs in various steps of gastric carcinogenesis: from gastritis toward metastatic disease. Great biological stability of miRNAs opens novel fields in biomarker research with potential clinical implementation in screening, diagnosis, prediction of prognosis and therapeutic management. In this review, we provide the basic knowledge of miRNA biogenesis and discuss extensively the role of miRNAs in gastric carcinogenesis, including Helicobacter pylori-related miRNA alterations and potential translational clinical implementations. Copyright (C) 2012 S. Karger AG, Basel