Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan
Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan
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DOI：
10.1016/j.psychres.2010.07.023
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发表时间：
2011-04-30
影响因子：
11.3
通讯作者：
Nakamura, Jun
中科院分区：
文献类型：
--
作者：
Okuno, Kanae;Yoshimura, Reiji;Nakamura, Jun
越来越多的证据表明，血液中脑源性神经营养因子（BDNF）和去甲肾上腺素的主要代谢物3-甲氧基-4-羟基苯乙二醇（MHPG）的水平与抑郁相关的人格特征以及抑郁，自杀和焦虑状态有关。众所周知，心理工作压力会导致抑郁、焦虑和自杀的症状。我们最近报道了医院员工的心理工作压力改变了BDNF和MHPG的血液水平（Mitoma等人，2008年）。在本研究中，我们重新研究了社会适应和人格特质，以及心理工作压力，对血浆BDNF和MHPG水平的健康员工（n = 269，男性/女性= 210/59，年龄= 49 +/- 10岁）在日本的一家出版公司工作。压力和唤醒检查表（s-SACL和a-SACL）、社会适应自我评价量表（SASS）、血浆MHPG水平和血浆BDNF水平的评分值（平均值+/- SD）分别为6.0 +/- 3.4、5.7 +/- 23、33.7 +/- 6.8、5.8 +/- 4.3和4.6 +/- 3.1 ng/ml（-1）。血浆MHPG水平与s-SACL评分呈正相关，但与a-SACL评分无相关性。SASS评分与血浆MHPG水平、血浆BDNF水平呈正相关。血浆BDNF水平与s-SACL评分呈负相关。此外，NEO-五因素量表（开放性）评分与血浆MHPG水平呈正相关，NEO-五因素量表（外向性）评分与血浆BDNF水平呈正相关。这些结果表明，血浆BDNF和血浆MHPG的水平可能与心理工作压力和某些人格特质在日本出版业的员工。(C)2010爱思唯尔爱尔兰有限公司版权所有。
There is growing evidence that blood levels of brain-derived neurotrophic factor (BDNF) and 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of noradrenaline, are related to depression-associated personality traits as well as to depressive, suicidal and anxious states. Psychological job stress is well known to lead to symptoms of depression, anxiety and suicide. We have recently reported that psychological job stress among hospital employees altered blood levels of BDNF and MHPG (Mitoma et al., 2008). In the present study, we re-examined the effects of social adaptation and personality traits, as well as those of psychological job stress, on plasma levels of BDNF and MHPG in healthy employees (n = 269, male/female = 210/59, age = 49 +/- 10 years) working in a publishing company in Japan. The values (mean +/- SD) of scores on the Stress and Arousal Check Lists (s-SACL and a-SACL), Social Adaptation Self-evaluation Scale (SASS), plasma MHPG levels and plasma BDNF levels were 6.0 +/- 3.4, 5.7 +/- 23, 33.7 +/- 6.8, 5.8 +/- 4.3 and 4.6 +/- 3.1 ng ml(-1), respectively. A positive correlation was found between plasma MHPG levels and scores on the s-SACL, but not the a-SACL. A positive correlation was also found between SASS scores and plasma MHPG levels and between SASS scores and plasma BDNF levels. A negative correlation was found between plasma BDNF levels and s-SACL scores. Furthermore, a positive correlation between NEO-Five factor Inventory (Openness) scores and plasma MHPG levels was observed, as well as between NEO-Five factor Inventory (Extroversion) scores and plasma BDNF levels. These results suggest that levels of plasma BDNF and plasma MHPG might be associated with psychological job stress and certain personality traits among employees in the publishing industry in Japan. (C) 2010 Elsevier Ireland Ltd. All rights reserved.