Blood-contacting magnetic levitation bearing design using computational fluid dynamics for haemocompatibility.
Blood-contacting magnetic levitation bearing design using computational fluid dynamics for haemocompatibility.
复制标题
使用计算流体动力学实现血液相容性的血液接触磁悬浮轴承设计。
DOI：
10.1109/embc40787.2023.10341056
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fraser,KatharineH
中科院分区：
文献类型：
--
作者：
Nissim,Lee;Karnik,Shweta;Kiang,Simon;Tedesco,Victor;Ogiwara,Eiji;Kurita,Nobuyuki;Wang,Yaxin;Frazier,OHoward;Fraser,KatharineH
血液相容性评估平台(HAP)是一个测试平台，可用于评估旋转血泵的各个组件造成的血液创伤，其中包括NeoVAD--一种建议的儿科左心室辅助装置(LVAD)。重要的是，HAP本身只有最低限度的溶血作用，因此所测得的血浆游离血红蛋白可以被认为来自测试成分。在这项研究中，进行了计算流体动力学模拟，为磁悬浮电机轴承间隙的设计提供了参考。模拟表明，通过引入一条将血流引入轴承中心并扰乱导致这些问题的二次流模式的管道，可以缓解原始设计中的问题，即停滞区和大回流区。临床相关性--随后剪切暴露时间的减少将减少HAP引起的血吸虫病。轴承的重新设计将减少HAP造成的基线血液损伤，从而可以量化测试组件的溶血，因此将有助于未来儿科LVAD的设计。
The Hemocompatibility Assessment Platform (HAP) is a testing rig that will allow for the evaluation of blood trauma caused by individual components of rotary blood pumps including the NeoVAD – a proposed paediatric Left Ventricular Assist Device (LVAD). It is important that the HAP itself is only minimally haemolytic such that the plasma free haemoglobin measured can be assumed to come from the test component. In this study, Computational Fluid Dynamics simulations have been carried out to inform the design of a magnetically levitated motor bearing gap. Simulations show that issues with the original design, namely stagnation regions and large recirculation zones can be mitigated with the introduction of a pipe that introduces blood-flow to the centre of the bearing and disrupts the secondary flow patterns that cause these issues.Clinical relevance— The consequent reduction in shear exposure time will reduce heamolsyis from the HAP. The redesign of the bearing will result in reduced baseline blood trauma from the HAP, thus allowing quantification of test component haemolysis and will therefore aid the design of future paediatric LVADs.