Telomere shortening with aging in the human pancreas
Telomere shortening with aging in the human pancreas
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DOI：
10.1016/j.exger.2006.06.036
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发表时间：
2006-09-01
影响因子：
3.9
通讯作者：
Takubo, Kaiyo
中科院分区：
文献类型：
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作者：
Ishii, Akio;Nakamura, Ken-Ichi;Takubo, Kaiyo
我们进行了系统研究来测量所有类型人体组织中的端粒长度。研究人员对 69 名 0 岁至 100 岁受试者尸检时获得的正常胰腺样本进行了随年龄增长而进行性端粒缩短的研究，发现与年龄相关的端粒长度以每年 36 个碱基对 (bp) 的速度缩短。 16 名新生儿的平均端粒长度 (+/- SD) 为 13.9 +/- 1.4 kbp，而 2 名百岁老人的平均端粒长度为 8.4 kbp。四个年龄组（0-24岁、25-49岁、50-74岁和75-100岁）的平均端粒长度（+/- SD）分别为13.5 +/- 1.5、12.3 +/- 0.7、11.3 +/- 2.5和10.7 +/- 1.8。 (c) 2006 Elsevier Inc. 保留所有权利。
We have conducted systematic studies to measure telomere length in human tissues of all types. Progressive telomere shortening with aging was studied in specimens of normal pancreas obtained at autopsy from 69 subjects aged 0 to 100 yr, and age-related shortening of telomere length at a rate of 36 base pairs (bp) per year was detected. Mean telomere length (+/- SD) was 13.9 +/- 1.4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/- SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5 +/- 1.5, 12.3 +/- 0.7, 11.3 +/- 2.5, and 10.7 +/- 1.8, respectively. (c) 2006 Elsevier Inc. All rights reserved.