Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
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DOI：
10.1074/jbc.273.7.4135
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发表时间：
1998-02-13
影响因子：
4.8
通讯作者：
Sanicola, M
中科院分区：
文献类型：
--
作者：
Ichimura, T;Bonventre, JV;Sanicola, M
我们报告的鉴定大鼠和人类的cDNA的1型膜蛋白，包含一个新的六个半胱氨酸免疫球蛋白样结构域和粘蛋白结构域，它被命名为肾损伤分子-1（KIM-1）。在结构上，KIM-1是免疫球蛋白基因超家族的成员，最能让人联想到粘膜地址素细胞粘附分子1（MAdCAM-1）。人KIM-1与最近被鉴定为甲型肝炎病毒受体的猴基因甲型肝炎病毒细胞受体1（HAVcr-1）具有同源性，KIM-1 mRNA和蛋白在正常肾脏中以低水平表达，但在缺血后肾脏中显著增加，原位杂交和免疫组化显示KIM-1在增殖的溴脱氧尿苷-再生近端小管中的波形蛋白阳性和去分化的波形蛋白阳性上皮细胞。结构和表达数据表明KIM-1是在细胞中上调的上皮细胞粘附分子，其被去分化并进行复制，KIM-1可能在缺血后肾脏形态和功能的恢复中起重要作用。
We report the identification of rat and human cDNAs for a type 1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1). Structurally, KIM-1 is a member of the immunoglobulin gene superfamily most reminiscent of mucosal addressin cell adhesion molecule 1 (MAdCAM-1). Human KIM-1 exhibits homology to a monkey gene, hepatitis A virus cell receptor 1 (HAVcr-1), which was identified recently as a receptor for the hepatitis A virus, KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased dramatically in postischemic kidney, In situ hybridization and immunohistochemistry revealed that KIM-1 is expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules, Structure and expression data suggest that KIM-1 is an epithelial cell adhesion molecule up-regulated in the cells, which are dedifferentiated and undergoing replication, KIM-1 may play an important role in the restoration of the morphological integrity and function to postischemic kidney.