Toxoplasma gondii Immunoglobulin G Antibodies and Nonfatal Suicidal Self-Directed Violence
Toxoplasma gondii Immunoglobulin G Antibodies and Nonfatal Suicidal Self-Directed Violence
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DOI：
10.4088/jcp.11m07532
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发表时间：
2012-08-01
影响因子：
5.3
通讯作者：
Postolache, Teodor T.
中科院分区：
文献类型：
--
作者：
Zhang, Yuanfen;Traskman-Bendz, Lil;Postolache, Teodor T.
目的：主要目的是将弓形虫血清阳性和血清强度与自测自杀评估量表（SUAS-S）评分相关联。另一个目的是重新评估先前报道的弓形虫血清强度与非致命性自杀自我导向暴力史之间的正相关性。这项横断面观察性研究比较了54名成人自杀者血浆中弓形虫血清强度和血清阳性率（瑞典隆德隆德大学医院的住院患者）和30名成年对照受试者（随机选择自瑞典隆德市人口登记处）。根据DSM-IV标准进行精神病诊断。检测血浆样本中的弓形虫、巨细胞病毒和单纯疱疹病毒1型免疫球蛋白G抗体。采用多变量Logistic回归分析数据，以探讨弓形虫血清强度或血清阳性与非致命性自杀自我导向暴力史之间的关系;采用多变量线性回归分析弓形虫血清强度或血清阳性与SUAS-S之间的关系。两个回归模型均以性别、年龄和体重指数为协变量。（调整后的比值比[OR]=7.12; 95%CI，1.66-30.6; P=.008）和弓形虫血清强度（调整后的OR=2.01; 95%CI，1.09-3.71; P=.03）与非致命性自杀性自我导向暴力史呈正相关。弓形虫血清阳性与较高的SUAS-S评分相关，整个样本的相关性显著（P= 0.026），但仅对自杀未遂者不相关。与其他病原体没有显着关联identified.Conclusions：这些结果是一致的，与以前的报告弓形虫感染和非致命性自杀自我导向的暴力之间的关联。在未来的大型纵向研究中证实这些结果，并将自杀作为一个结果，可能会导致自杀预防的新的个性化方法。J Clin Psychiatry 2012;73（8）：1069-1076（c）版权所有2012 Physicians Postgraduate Press，Inc.
Objective: The primary aim was to relate Toxoplasma gondii seropositivity and serointensity to scores on the self-rated Suicide Assessment Scale (SUAS-S). Another aim was to reevaluate the previously reported positive association between T gondii serointensity and a history of nonfatal suicidal self-directed violence.Method: This cross-sectional, observational study compared T gondii serointensity and seropositivity in plasma from 54 adult suicide attempters (inpatients at Lund University Hospital, Lund, Sweden) and 30 adult control subjects (randomly selected from the municipal population register in Lund, Sweden) recruited between 2006 and 2010.The potential of patients and controls for self-directed violence was evaluated with the SUAS-S. Psychiatric diagnoses were made according to DSM-IV criteria. Plasma samples were tested for immunoglobulin G antibodies to T gondii, cytomegalovirus, and herpes simplex virus type 1. Data were analyzed using multivariable logistic regression to investigate the association between T gondii serointensity or seropositivity and a history of nonfatal suicidal self-directed violence; multivariable linear regression was used to explore the relationship between T gondii serointensify or seropositivity and the SUAS-S. Both regression models included sex, age, and body mass index as covariates.Results: Seropositivity of T gondii (adjusted odds ratio [OR]=7.12; 95% CI, 1.66-30.6; P=.008) and serointensity of T gondii (adjusted OR=2.01; 95% CI, 1.09-3.71; P=.03) were positively associated with a history of nonfatal suicidal self-directed violence. Seropositivity of T gondii was associated with higher SUAS-S scores, a relationship significant for the whole sample (P=.026), but not for suicide attempters only. No significant associations with other pathogens were identified.Conclusions: These results are consistent with previous reports on the association between T gondii infection and nonfatal suicidal self-directed violence. Confirming these results in future large longitudinal studies and including suicide as an outcome may lead to novel individualized approaches in suicide prevention. J Clin Psychiatry 2012;73 (8):1069-1076 (c) Copyright 2012 Physicians Postgraduate Press, Inc.