Structural Design of Stimuli-Responsive Bioconjugated Hydrogels That Respond to a Target Antigen
Structural Design of Stimuli-Responsive Bioconjugated Hydrogels That Respond to a Target Antigen
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DOI：
10.1002/polb.21812
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发表时间：
2009-11-01
影响因子：
--
通讯作者：
Uragami, Tadashi
中科院分区：
文献类型：
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作者：
Miyata, Takashi;Asami, Noriko;Uragami, Tadashi
通过将抗原-抗体结合作为可逆交联引入到凝胶网络中来制备可以响应于靶抗原的刺激响应性生物缀合水凝胶（抗原响应性水凝胶）。研究了抗原响应性水凝胶的制备条件和抗原响应性的机理，重点研究了生物偶联水凝胶的结构。本文还重点研究了半互穿聚合物网络（semi-IPN）结构对具有抗原-抗体结合的生物缀合水凝胶的抗原响应性溶胀/收缩行为的影响。讨论了生物共轭水凝胶的制备条件和网络结构，为设计抗原响应性水凝胶提供了依据。(C)2009 Wiley Periodicals，Inc.聚合物科学杂志B部分：聚合物物理47：2144-2157，2009
Stimuli-responsive bioconjugated hydrogels that can respond to a target antigen (antigen-responsive hydrogels) were prepared by introducing antigen-antibody bindings as reversible crosslinks into the gel networks. The preparation conditions of the antigen-responsive hydrogels and the mechanism of the antigen-responsive behavior were investigated, focusing on bioconjugated hydrogel structures. This article also focuses on the effect of semi-interpenetrating polymer network (semi-IPN) structures on the antigen-responsive swelling/shrinking behavior of bioconjugated hydrogels with antigen-antibody bindings. The preparation conditions and the network structures of the bioconjugated hydrogels are discussed in relation to designing antigen-responsive hydrogels. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 2144-2157, 2009