NKT cells in the induced sputum of severe asthmatics
NKT cells in the induced sputum of severe asthmatics
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DOI：
10.1155/mi/2006/71214
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发表时间：
2006-01-01
影响因子：
4.6
通讯作者：
Hamzaoui, Kamel
中科院分区：
文献类型：
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作者：
Hamzaoui, Agnes;Rouhou, Sana Cheik;Hamzaoui, Kamel
为了确定重症哮喘患者是否存在特定的炎症过程，对重症哮喘患者诱导痰免疫细胞的表型特征进行了分析。研究了22份诱导痰样本（来自10名重症哮喘患者）。使用痰液免疫细胞以及针对CD3、CD4、CD8、CD56、CD25和TCR.d的单克隆抗体进行流式细胞术分析。与轻度哮喘组和健康对照组相比，重症哮喘患者痰液中NKT（CD3(+)CD56(+)）细胞的数量显著更高（P
To determine whether there was a specific inflammatory process in severe asthmatics, the phenotypic characteristics of induced sputum immune cells were analysed among patients with severe asthma. Twenty-two induced sputa (10 severe asthmatics) were studied. Flow cytometric analysis was performed using immune cells of the sputum and monoclonal antibodies to CD3, CD4, CD8, CD56, CD25, and TCR.d. The number of NKT (CD3(+)CD56(+)) cells was significantly higher in the sputum of severe asthmatics compared with mild asthmatic and healthy control groups (P